Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms
Symmetry of ictal slow waves may predict the outcomes of corpus callosotomy for epileptic spasms
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DOI：
10.1038/s41598-019-56303-3
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发表时间：
2019-12-24
影响因子：
4.6
通讯作者：
Fujimoto, Ayataka
中科院分区：
文献类型：
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作者：
Kanai, Sotaro;Oguri, Masayoshi;Fujimoto, Ayataka
我们的目的是分析发作期头皮脑电图（EEG）的变化，重点是癫痫痉挛（ES）和强直性痉挛（TS）儿童的高压慢波（HVS），然后确定与胼胝体切开术（CC）结局相关的因素。我们招募了17名ES/TS患者，他们在20岁之前接受了CC。CC后恩格尔的分类如下：7例患者为I级，2例患者为II级，4例患者为III级，4例患者为IV级。Welch t检验用于分析发作HVS和CC结果之间的相关性，基于以下三个对称指标：（1）负峰延迟：负峰之间的半球间延迟;（2）振幅比：最高正峰的振幅值的半球间比率;和（3）持续时间比：慢波持续时间的半球间比率。CC的年龄范围为17-237个月。分析了每例患者的4至15次发作期EEG。负峰延迟、振幅比和持续时间比分别为0-530 ms、1.00-7.40和1.00-2.74。癫痫残留组的负峰延迟、振幅比和持续时间比显著更高（p = 0.017，
We aimed to analyse the ictal electrographic changes on scalp electroencephalography (EEG), focusing on high-voltage slow waves (HVSs) in children with epileptic spasms (ES) and tonic spasms (TS) and then identified factors associated with corpus callosotomy (CC) outcomes. We enrolled 17 patients with ES/TS who underwent CC before 20 years of age. Post-CC Engel's classification was as follows: I in 7 patients, II in 2, III in 4, and IV in 4. Welch's t-test was used to analyse the correlation between ictal HVSs and CC outcomes based on the following three symmetrical indices: (1) negative peak delay: interhemispheric delay between negative peaks; (2) amplitude ratio: interhemispheric ratio of amplitude values for the highest positive peaks; and (3) duration ratio: interhemispheric ratio of slow wave duration. Ages at CC ranged from 17-237 months. Four to 15 ictal EEGs were analysed for each patient. The negative peak delay, amplitude ratio and duration ratio ranged from 0-530 ms, 1.00-7.40 and 1.00-2.74, respectively. The negative peak delay, amplitude ratio and duration ratio were significantly higher in the seizure residual group (p = 0.017,