Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period.
Acquisition of innate odor preference depends on spontaneous and experiential activities during critical period.
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作者：
Qiu Q;Wu Y;Ma L;Xu W;Hills M Jr;Ramalingam V;Yu CR
动物天生具有识别某些气味的能力，以躲避捕食者、寻找食物和寻找配偶。天生的气味偏好被认为是遗传的。在这里，我们报告先天性气味识别的获得需要自发的神经活动，并在出生后早期发育过程中受到感官经验的影响。小鼠嗅觉感觉神经元在关键时期的基因沉默对以后的气味敏感性、辨别和识别几乎没有影响。然而，它消除了先天的气味偏好，并改变了大脑中心的激活模式。在关键时期暴露在先天识别的气味中，在成年期以气味特异性的方式消除了相关的价。这种变化与嗅觉感觉神经元的投射变宽和轴突引导分子的表达有关。因此，在建立先天气味偏好的关键时期，神经活动需要一个微妙的平衡，而编码先天气味价则需要收敛轴突输入。
Animals possess an inborn ability to recognize certain odors to avoid predators, seek food, and find mates. Innate odor preference is thought to be genetically hardwired. Here we report that acquisition of innate odor recognition requires spontaneous neural activity and is influenced by sensory experience during early postnatal development. Genetic silencing of mouse olfactory sensory neurons during the critical period has little impact on odor sensitivity, discrimination, and recognition later in life. However, it abolishes innate odor preference and alters the patterns of activation in brain centers. Exposure to innately recognized odors during the critical period abolishes the associated valence in adulthood in an odor-specific manner. The changes are associated with broadened projection of olfactory sensory neurons and expression of axon guidance molecules. Thus, a delicate balance of neural activity is needed during the critical period in establishing innate odor preference and convergent axon input is required to encode innate odor valence.