Mammalian odorant receptors: functional evolution and variation.
Mammalian odorant receptors: functional evolution and variation.
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DOI：
10.1016/j.conb.2015.01.014
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发表时间：
2015-10
影响因子：
5.7
通讯作者：
Matsunami H
中科院分区：
文献类型：
--
作者：
Jiang Y;Matsunami H
在哺乳动物中，嗅觉的感知始于环境中挥发性分子激活气味受体（OR）。哺乳动物的 OR 库经历了快速进化，并且在人类群体中高度多样化。 OR 功能表达和配体鉴定的最新进展允许对 OR 进化进行功能分析，并揭示 OR 蛋白质序列的变化转化为高度的功能变异。此外，在某些情况下，单个 OR 的功能变化会影响其同源气味配体的感知，从而为气味如何在受体水平编码提供线索。
In mammals, the perception of smell starts with the activation of odorant receptors (ORs) by volatile molecules in the environment. The mammalian OR repertoire has been subject to rapid evolution, and is highly diverse within the human population. Recent advances in the functional expression and ligand identification of ORs allow for functional analysis of OR evolution, and reveal that changes in OR protein sequences translate into high degrees of functional variations. Moreover, in several cases the functional variation of a single OR affects the perception of its cognate odor ligand, providing clues as to how an odor is coded at the receptor level.