Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces
Selective Formation of Porous Pt Nanorods for Highly Electrochemically Efficient Neural Electrode Interfaces
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DOI：
10.1021/acs.nanolett.9b02296
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发表时间：
2019-09-01
期刊：
影响因子：
10.8
通讯作者：
Dayeh, Shadi A.
中科院分区：
文献类型：
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作者：
Ganji, Mehran;Paulk, Angelique C.;Dayeh, Shadi A.
纳米结构材料的增强的电化学活性很容易在能量设备中被利用，但是它们在可扩展和人类兼容的可植入神经接口中的实用性可以显着提高临床和研究电极的性能。我们利用低温选择性去合金化来开发可扩展和生物相容的一维铂纳米棒（PtNR）阵列，这些阵列在各种长度尺度下表现出优异的电化学性能，稳定性和生物相容性，用于高性能神经技术。PtNR阵列记录了鸟类和非人类灵长类动物皮层表面的细胞分辨率的大脑活动。值得注意的是，强烈的调制表面记录的单单位活动的听觉刺激，在欧洲八哥鸟类以及调制的局部场电位在视觉皮层的光刺激在非人类灵长类动物和小鼠的电刺激的反应。PtNRs以高时空分辨率从大脑表面记录行为和生理相关的神经元动力学，这为侵入性更小的脑机接口铺平了道路。
The enhanced electrochemical activity of nanostructured materials is readily exploited in energy devices, but their utility in scalable and human-compatible implantable neural interfaces can significantly advance the performance of clinical and research electrodes. We utilize low-temperature selective dealloying to develop scalable and biocompatible one-dimensional platinum nanorod (PtNR) arrays that exhibit superb electrochemical properties at various length scales, stability, and biocompatibility for high performance neurotechnologies. PtNR arrays record brain activity with cellular resolution from the cortical surfaces in birds and nonhuman primates. Significantly, strong modulation of surface recorded single unit activity by auditory stimuli is demonstrated in European Starling birds as well as the modulation of local field potentials in the visual cortex by light stimuli in a nonhuman primate and responses to electrical stimulation in mice. PtNRs record behaviorally and physiologically relevant neuronal dynamics from the surface of the brain with high spatiotemporal resolution, which paves the way for less invasive brain-machine interfaces.