Structural Differences in Hippocampal and Prefrontal Gray Matter Volume Support Flexible Context-Dependent Navigation Ability
Structural Differences in Hippocampal and Prefrontal Gray Matter Volume Support Flexible Context-Dependent Navigation Ability
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DOI：
10.1523/jneurosci.2202-13.2014
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发表时间：
2014-02-05
影响因子：
5.3
通讯作者：
Stern, Chantal E.
中科院分区：
文献类型：
--
作者：
Brown, Thackery I.;Whiteman, Andrew S.;Stern, Chantal E.
空间导航是日常生活的基本组成部分。人类灵活驾驭世界的个人能力是不同的，关键问题是这种可变性与潜在大脑结构的差异有何关系。我们的实验考察了灵活导航能力的个体差异，这些能力与先前学习的轨迹重叠，并且必须与之区分开来。我们使用基于体素的形态测量法将健康年轻人灵活导航性能的差异与大脑形态的差异联系起来。我们的发现提供了新的证据，表明海马和背外侧前额皮质灰质体积的个体差异与我们快速学习和灵活地在世界中导航的能力有关。
Spatial navigation is a fundamental part of daily life. Humans differ in their individual abilities to flexibly navigate their world, and a critical question is how this variability relates to differences in underlying brain structure. Our experiment examined individual differences in the ability to flexibly navigate routes that overlap with, and must be distinguished from, previously learned trajectories. We related differences in flexible navigation performance to differences in brain morphology in healthy young adults using voxel-based morphometry. Our findings provide novel evidence that individual differences in gray matter volume in the hippocampus and dorsolateral prefrontal cortex correlate with our ability rapidly to learn and flexibly navigate routes through our world.