[Assessment of the response to reduced treatment schemes for vivax malaria].
[Assessment of the response to reduced treatment schemes for vivax malaria].
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DOI：
10.1590/s0037-86822001000400006
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发表时间：
2001-07-01
影响因子：
2
通讯作者：
de Souza, J M
中科院分区：
文献类型：
--
作者：
Abdon, N P;Pinto, A Y;de Souza, J M
间日疟的长期标准治疗可能会复发，这是由于患者的依从性不完全造成的。使用减少的时间表可能会进一步改善患者的依从性，同时保持相同的疗效、耐受性和最小的不良反应。这项研究的目的是测试两种减少剂量的氯喹治疗间日疟的方案，并将这些方案与经典方案进行比较。作者对120例12岁以上间日疟患者进行了3种治疗方案的研究：方案1：磷酸氯喹150 mg，每日25 mg/kg，连用3天(第1天10 mg/kg，第2、3天7.5 mg/kg/d)，加伯氨喹15 mg，每日0.25 mg/kg，连用14天，方案II：氯喹10 mg/kg，加伯氨喹0.5 mg/kg，连用7天；方案三：氯喹10 mg/kg/次，加伯氨喹0.5 mg/kg/d，连服5天。三种治疗方案的临床疗效均令人满意。在所有治疗方案中，疟疾症状最多在治疗96小时后消失，而无性寄生虫血症在72小时内消失。
Relapses may occur with long standard treatment of vivax malaria, and these are caused by incomplete patient's compliance. The use of reduced schedules may further better patient compliance, while maintaining the same efficacy, tolerance and minimal adverse reactions. The objective of this study was to test two schedules with reduced doses of chloroquine for vivax malaria and comparing these with the classical schedule. The authors studied 120 outpatients, with vivax malaria, aged over 12 years, submitted to three therapeutic schemes: scheme I: chloroquine phosphate (150 mg) in a dose of 25mg/kg/day for three days (10mg/kg/ day in the first day, 7.5mg/kg/day in the second and third day), plus primaquine (15 mg) in a dose of 0.25mg/kg/day for fourteen days; scheme II: chloroquine, in a single dose of 10mg/kg, plus primaquine in a dose of 0.5mg/kg/day for seven days; scheme III: chloroquine, 10mg/kg in a single dose plus primaquine in a dose 0.5mg/kg/ day for five days. The clinical response to all three therapeutic schemes was satisfactory. The disappearance of malarial symptoms occurred after a maximum 96 hours of treatment, while the asexual parasitaemia clearance occurred within 72 hours, in all therapeutic schemes.