Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma
Long noncoding RNA IRAIN acts as tumor suppressor via miR-125b in multiple myeloma
复制标题
长非编码 RNA IRAIN 通过 miR-125b 在多发性骨髓瘤中发挥肿瘤抑制作用
DOI：
10.3892/ol.2019.11012
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发表时间：
2019
期刊：
影响因子：
2.9
通讯作者：
Guoan Chen
中科院分区：
文献类型：
--
作者：
Jiang Yanxia;Jian Chen;Guoan Chen
Long noncoding RNAs (lncRNAs) are aberrantly expressed in a variety of cancer types. The lncRNA IGF1R antisense imprinted non-protein coding RNA (IRAIN) is associated with various cancer types, yet the role of IRAIN in multiple myeloma (MM) progression remains unclear. In the present study it was identified that IRAIN may act as a tumor suppressor in MM, whilst microRNA (miR)-125b may promote tumorigenesis. Downregulation of IRAIN significantly increased the expression of miR-125b. Furthermore, by using dual-luciferase reporter assays, IRAIN was identified as a target of miR-125b. Knockdown of IRAIN promoted MM cell proliferation in vitro . Thus, expression levels of IRAIN may be used to predict the clinical prognosis of patients with MM and may be a novel therapeutic target for treating MM.
