Predictors of blood trihalomethane concentrations in NHANES 1999-2006.
Predictors of blood trihalomethane concentrations in NHANES 1999-2006.
复制标题
DOI：
10.1289/ehp.1306499
复制
发表时间：
2014-07
影响因子：
10.4
通讯作者：
Steenland K
中科院分区：
文献类型：
--
作者：
Riederer AM;Dhingra R;Blount BC;Steenland K
背景：三卤甲烷（THMs）是水消毒副产物，与膀胱癌和不良分娩结局有关。在1999-2006年美国国家健康与营养调查（NHANES）中，测定了美国成年人血液和自来水中的四种thm（溴仿、氯仿、溴二氯甲烷、二溴氯甲烷）。THMs通过细胞色素p450 (CYP) 2D6和CYP2E1酶代谢为潜在毒性/致突变中间体。目的：我们对血液THMs进行探索性分析，包括影响CYP2D6和CYP2E1活性的因素。方法：我们使用加权多变量回归来评估血液中THM与水浓度、调查年份以及其他可能影响THM暴露或代谢的因素（如处方药、十字花科蔬菜、糖尿病、禁食、怀孕、游泳）之间的关系。结果：1999 - 2006年，血液和水中THM几何平均水平呈平行下降趋势，血液和水中THM几何平均水平分别下降32% ~ 76%和38% ~ 52%，部分原因可能是2002-2004年饮用水THM总标准的降低。血液THM水平的最强预测因子是调查年份和水浓度（n = 4,232总THM； n = 4,080溴仿；n = 4,582氯仿；n = 4,374溴二氯甲烷；n = 4,464二溴氯甲烷）。我们在除溴仿模型外的所有模型中发现了与糖尿病和食用十字花科蔬菜有统计学意义的负相关。药物并不能始终如一地预测血液水平。下午/晚上的血液样本THM浓度低于早上的样本。在一个亚样本（n = 230）中，空气氯仿比水氯仿更能预测血液氯仿，这表明淋浴/沐浴是比饮用更重要的来源。结论：我们确定了与血液thm相关的几个可能影响其代谢的因素。潜在的健康影响需要进一步研究。引用本文：Riederer AM， dingra R, Blount BC, Steenland K. 2014。1999-2006年NHANES中血液三卤甲烷浓度的预测因子。环境健康展望122:695-702；http://dx.doi.org/10.1289/ehp.1306499
Background: Trihalomethanes (THMs) are water disinfection by-products that have been associated with bladder cancer and adverse birth outcomes. Four THMs (bromoform, chloroform, bromodichloromethane, dibromochloromethane) were measured in blood and tap water of U.S. adults in the National Health and Nutrition Examination Survey (NHANES) 1999–2006. THMs are metabolized to potentially toxic/mutagenic intermediates by cytochrome p450 (CYP) 2D6 and CYP2E1 enzymes. Objectives: We conducted exploratory analyses of blood THMs, including factors affecting CYP2D6 and CYP2E1 activity. Methods: We used weighted multivariable regressions to evaluate associations between blood THMs and water concentrations, survey year, and other factors potentially affecting THM exposure or metabolism (e.g., prescription medications, cruciferous vegetables, diabetes, fasting, pregnancy, swimming). Results: From 1999 to 2006, geometric mean blood and water THM levels dropped in parallel, with decreases of 32%–76% in blood and 38%–52% in water, likely resulting, in part, from the lowering of the total THM drinking water standard in 2002–2004. The strongest predictors of blood THM levels were survey year and water concentration (n = 4,232 total THM; n = 4,080 bromoform; n = 4,582 chloroform; n = 4,374 bromodichloromethane; n = 4,464 dibromochloromethane). We detected statistically significant inverse associations with diabetes and eating cruciferous vegetables in all but the bromoform model. Medications did not consistently predict blood levels. Afternoon/evening blood samples had lower THM concentrations than morning samples. In a subsample (n = 230), air chloroform better predicted blood chloroform than water chloroform, suggesting showering/bathing was a more important source than drinking. Conclusions: We identified several factors associated with blood THMs that may affect their metabolism. The potential health implications require further study. Citation: Riederer AM, Dhingra R, Blount BC, Steenland K. 2014. Predictors of blood trihalomethane concentrations in NHANES 1999–2006. Environ Health Perspect 122:695–702; http://dx.doi.org/10.1289/ehp.1306499
登录
查看更多内容
影响因子：
10.4
作者：
Cantor KP;Villanueva CM;Silverman DT;Figueroa JD;Real FX;Garcia-Closas M;Malats N;Chanock S;Yeager M;Tardon A;Garcia-Closas R;Serra C;Carrato A;Castaño-Vinyals G;Samanic C;Rothman N;Kogevinas M
通讯作者：
Kogevinas M
DOI：
10.3200/aeoh.60.1.7-15
发表时间：
2005-01-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Ashley, David L.;Blount, Benjamin C.;Masters, John
通讯作者：
Masters, John
影响因子：
9.8
作者：
Batterman, S;Zhang, L;Franzblau, A
通讯作者：
Franzblau, A
影响因子：
5.1
作者：
Allis, JW;Zhao, GY
通讯作者：
Zhao, GY
DOI：
10.1080/15298660108984622
发表时间：
2001-03-01
期刊：
AIHAJ
影响因子：
--
作者：
Finkelstein, MM;Verma, DK
通讯作者：
Verma, DK