Nuclear magnetic resonance imaging of experimentally induced liver disease.
Nuclear magnetic resonance imaging of experimentally induced liver disease.
复制标题
实验诱发的肝病的核磁共振成像。
DOI：
10.1148/radiology.148.3.6192464
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发表时间：
1983
期刊：
影响因子：
19.7
通讯作者：
Goldberg,HI
中科院分区：
文献类型：
--
作者：
Stark,DD;Bass,NM;Moss,AA;Bacon,BR;McKerrow,JH;Cann,CE;Brito,A;Goldberg,HI
使用3.5-kGauss核磁共振（NMR）成像系统评价肝炎、脂肪肝和肝铁过载的实验动物模型。图像强度测量值和T2弛豫时间的增加等于检测早期肝炎的组织学结果的灵敏度。T1弛豫时间的显著变化表征了肝坏死的早期阶段。肝脏甘油三酯含量与NMR强度测量值的增加显著相关（p <0.01）;然而，肝脏含水量的变化对强度、T1和T2的影响更大。因此，有可能将肝炎与良性脂肪肝区分开来。肝脏铁含量与NMR强度测量值的降低相关（p <0.001），检测到的铁水平低至1.2 mg/g。核磁共振可以更具体地确定肝细胞铁超载比其他技术，不区分肝细胞网状内皮铁。
Experimental animal models of hepatitis, fatty liver, and hepatic iron overload were evaluated using a 3.5-kGauss nuclear magnetic resonance (NMR) imaging system. Increases in image intensity measurements and in T2 relaxation times equalled the sensitivity of histologic findings for the detection of early stages of hepatitis. A significant shift in T1 relaxation times characterized the early stages of hepatic necrosis. Liver triglyceride content correlated significantly with increases in NMR intensity measurements (p less than 0.01); however, changes in liver water content had a much greater influence on intensity, T1, and T2. Thus, it may be possible to distinguish hepatitis from benign fatty liver. Liver iron content correlated with decreases in NMR intensity measurements (p less than 0.001), and iron levels as low as 1.2 mg/g were detected. NMR may more specifically identify hepatocellular iron overload than do other techniques that do not distinguish hepatocellular from reticuloendothelial iron.