Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study
Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study
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DOI：
10.5551/jat.13599
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发表时间：
2012-01-01
影响因子：
4.4
通讯作者：
Okamura, Tomonori
中科院分区：
文献类型：
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作者：
Higashiyama, Aya;Wakabayashi, Ichiro;Okamura, Tomonori
目的：高敏C-反应蛋白（hs-CRP）可识别处于心血管疾病（CVD）风险中且低密度脂蛋白胆固醇（LDL-C）水平未升高的个体。本研究旨在比较日本社区居民中hs-CRP和LDL-C与心踝血管指数（CAVI）的相关性，这些居民被认为是动脉粥样硬化的低风险人群，与传统的CVD危险因素水平不同。一项涉及386名健康日本人的基于社区的研究（261名男性和125名女性），无CVD病史和高血压、糖尿病和血脂异常药物。采用线性回归模型进行多重校正，以估计CAVI与hs-CRP或LDL-C水平之间的相关性。参与者被分为四组的基础上，他们是否高于或低于中位hs-CRP和LDL-C值，和CAVI之间进行了比较，通过协方差分析后调整混杂因素。结果：在多元线性回归模型中，hs-CRP显示出显着的正相关性与CAVI，但是，没有明确的关联CAVI和LDL-C之间观察。这些结果在LDL-C < 140 mg/dL或hs-CRP < 1.0 mg/L的参与者中的分析中相似。CAVI高hs-CRP组高于低hs-CRP组，不考虑LDL-C;然而，CAVI是最高的组与高LDL-C和高hs-CRP.Conclusions：本研究表明，hs-CRP可能是一个更好的危险因素评估动脉粥样硬化比LDL-C的个体被认为是动脉粥样硬化的低风险评估其传统的CVD危险因素。动脉粥样硬化血栓杂志，2012; 19：1027-1034。
Aim: High-sensitivity C-reactive protein (hs-CRP) identifies individuals at risk for cardiovascular disease (CVD) without an increased level of low-density lipoprotein cholesterol (LDL-C). The present study was performed to compare hs-CRP and LDL-C in association with the cardio-ankle vascular index (CAVI) in Japanese community dwellers considered to be at low risk for atherosclerosis from their level of traditional CVD risk factors.Methods: A community-based study involving 386 healthy Japanese (261 men and 125 women) without a history of CVD and medications for hypertension, diabetes, and dyslipidemia was performed. Multiple adjustments were performed with linear regression models to estimate the association between CAVI and hs-CRP or LDL-C levels. The participants were divided into four groups on the basis of whether they were above or below the median hs-CRP and LDL-C values, and CAVI was compared among the four groups by analysis of covariance after adjusting for confounders.Results: In multiple linear regression models, hs-CRP showed a significant positive association with CAVI; however, no clear association was observed between CAVI and LDL-C. These results were similar in the analyses among the participants with LDL-C < 140 mg/dL or hs-CRP < 1.0 mg/L. CAVI was higher in the groups with high hs-CRP than in those with low hs-CRP, irrespective of LDL-C; however, CAVI was highest in the group with high LDL-C and high hs-CRP.Conclusions: The present study suggests that hs-CRP could be a better risk factor assessor for atherosclerosis than LDL-C in individuals considered to be at low risk for atherosclerosis assessed by their traditional CVD risk factors. J Atheroscler Thromb, 2012; 19: 1027-1034.