Dental-Derived Mesenchymal Stem Cells: State of the Art.
Dental-Derived Mesenchymal Stem Cells: State of the Art.
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DOI：
10.3389/fcell.2021.654559
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发表时间：
2021
影响因子：
5.5
通讯作者：
Men Y
中科院分区：
文献类型：
--
作者：
Li B;Ouchi T;Cao Y;Zhao Z;Men Y
间充质干细胞（MSC）可以在哺乳动物牙齿中鉴定。目前，牙源性间充质干细胞（dental-derived MSCs，DMSCs）已成为所有从牙髓、牙周膜、牙囊、根尖乳头甚至牙龈中分离的MSCs的总称。这些DMSC具有与骨髓来源的MSC相似的多能潜能，包括分化成具有成牙本质细胞、成牙骨质细胞、成骨细胞、软骨细胞、肌细胞、上皮细胞、神经细胞、肝细胞和脂肪细胞特征的细胞。此外，DMSC还具有强大的免疫调节功能，使其能够协调周围的免疫微环境。这些特性使DMSC在损伤修复、组织再生和各种疾病的治疗中具有很有前途的方法。本文综述了DMSC功能和应用的最新进展，并阐明了这些进展如何为基于DMSC的治疗铺平道路。
Mesenchymal stem cells (MSCs) could be identified in mammalian teeth. Currently, dental-derived MSCs (DMSCs) has become a collective term for all the MSCs isolated from dental pulp, periodontal ligament, dental follicle, apical papilla, and even gingiva. These DMSCs possess similar multipotent potential as bone marrow-derived MSCs, including differentiation into cells that have the characteristics of odontoblasts, cementoblasts, osteoblasts, chondrocytes, myocytes, epithelial cells, neural cells, hepatocytes, and adipocytes. Besides, DMSCs also have powerful immunomodulatory functions, which enable them to orchestrate the surrounding immune microenvironment. These properties enable DMSCs to have a promising approach in injury repair, tissue regeneration, and treatment of various diseases. This review outlines the most recent advances in DMSCs’ functions and applications and enlightens how these advances are paving the path for DMSC-based therapies.
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