BDNF-TrkB signaling and neuroprotection in schizophrenia.
BDNF-TrkB signaling and neuroprotection in schizophrenia.
复制标题
DOI：
10.1016/j.ajp.2012.08.010
复制
发表时间：
2013-02
影响因子：
9.5
通讯作者：
Pillai, Anilkumar
中科院分区：
文献类型：
--
作者：
Pandya, Chirayu D;Kutiyanawalla, Ammar;Pillai, Anilkumar
脑源性神经营养因子（BDNF）等神经营养因子在神经元存活、突触可塑性和认知功能中起着至关重要的作用。已知BDNF通过酪氨酸激酶受体B （TrkB）激活触发的多种细胞内信号通路介导其作用。来自临床和临床前研究的证据表明，精神分裂症患者的BDNF信号发生了改变。此外，一些抗精神病药物对精神分裂症受试者和精神分裂症动物模型中的BDNF水平都有时间依赖性作用。鉴于对精神分裂症神经可塑性的兴趣日益浓厚，了解BDNF信号的神经保护和细胞存活作用将增强我们对其多种作用的认识，这可能会导致更有效的精神分裂症治疗。本文将概述BDNF信号在精神分裂症病理生理和治疗中的作用的最新发现，并特别关注其神经保护作用。
Neurotrophins such as brain-derived neurotropic factor (BDNF), play critical role in neuronal survival, synaptic plasticity and cognitive functions. BDNF is known to mediate its action through various intracellular signaling pathways triggered by activation of tyrosine kinase receptor B (TrkB). Evidence from clinical as well as pre-clinical studies indicate alterations in BDNF signaling in schizophrenia. Moreover, several antipsychotic drugs have time-dependent effects on BDNF levels in both schizophrenia subjects and animal models of schizophrenia. Given the emerging interest in neuroplasticity in schizophrenia understanding the neuroprotective and cell survival roles of BDNF signaling will enhance our knowledge of its diverse effects, which may lead to more effective treatments for schizophrenia. This article will present an overview of recent findings on the role of BDNF signaling in the pathophysiology and treatment of schizophrenia, with a special focus on its neuroprotective effects.