Interactions of Human Endothelial Cells with Gold Nanoparticles of Different Morphologies
Interactions of Human Endothelial Cells with Gold Nanoparticles of Different Morphologies
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DOI：
10.1002/smll.201101422
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发表时间：
2012-01-09
期刊：
影响因子：
13.3
通讯作者：
Kanaras, Antonios G.
中科院分区：
文献类型：
--
作者：
Bartczak, Dorota;Muskens, Otto L.;Kanaras, Antonios G.
研究了非癌原代内皮细胞与具有不同形态但具有相同配体帽的金纳米颗粒之间的相互作用。将内皮细胞与金纳米球、纳米棒、中空金球和核/壳二氧化硅/金纳米晶体一起孵育，其用单羧基（1-巯基十一碳-11-基）六乙二醇（OEG）包被。细胞活力研究表明，所有类型的金颗粒是非细胞毒性的。使用电感耦合等离子体（ICP）的细胞所采取的颗粒的数量估计，并发现不同的颗粒形态。上述结果是相对于加热效率进行讨论的。使用先前报道的实验数据和考虑到细胞微环境中颗粒的物理性质和分布的理论模型计算，发现必须包括装载有纳米颗粒的几个细胞的集体加热效应来解释所观察到的内皮细胞的活力。
The interactions between noncancerous, primary endothelial cells and gold nanoparticles with different morphologies but the same ligand capping are investigated. The endothelial cells are incubated with gold nanospheres, nanorods, hollow gold spheres, and core/shell silica/gold nanocrystals, which are coated with monocarboxy (1-mercaptoundec-11-yl) hexaethylene glycol (OEG). Cell viability studies show that all types of gold particles are noncytotoxic. The number of particles taken up by the cells is estimated using inductively coupled plasma (ICP), and are found to differ depending on particle morphology. The above results are discussed with respect to heating efficiency. Using experimental data reported earlier and theoretical model calculations which take into account the physical properties and distribution of particles in the cellular microenvironment, it is found that collective heating effects of several cells loaded with nanoparticles must be included to explain the observed viability of the endothelial cells.