A novel, highly selective, and general methodology for the synthesis of 1,5-diene-containing oligoisoprenoids of all possible geometrical combinations exemplified by an iterative and convergent synthesis of coenzyme Q(10).
A novel, highly selective, and general methodology for the synthesis of 1,5-diene-containing oligoisoprenoids of all possible geometrical combinations exemplified by an iterative and convergent synthesis of coenzyme Q(10).
复制标题
DOI：
10.1021/ol010263d
复制
发表时间：
2002-01
期刊：
影响因子：
5.2
通讯作者：
E. Negishi;Show-Yee Liou;Caiding Xu;Shouquan Huo
中科院分区：
文献类型：
--
作者：
E. Negishi;Show-Yee Liou;Caiding Xu;Shouquan Huo
[reaction: see text] A truly general, versatile, and highly regio- and stereoselective methodology for the synthesis of terpenoids containing 1,5-diene units of E and/or Z geometry critically involves Pd-catalyzed homoallyl- and homopropargyl-alkenyl coupling and Zr-catalyzed carboalumination of alkynes. By using this methodology, coenzyme Q(10), (E,Z,E)-geranylgeranoil, and other natural or unnatural compounds have been synthesized efficiently.
