Human susceptibility to legionnaires' disease.
Human susceptibility to legionnaires' disease.
复制标题
DOI：
10.1007/978-1-62703-161-5_33
复制
发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Hawn, Thomas R
中科院分区：
文献类型：
--
作者：
Berrington, William R;Hawn, Thomas R
嗜肺军团菌是一种兼性细胞内病原菌，是引起肺炎的重要原因。虽然可能易患军团病（LD）的宿主因素包括共病（如糖尿病、慢性肺病）、年龄、男性和吸烟，但许多个体没有可识别的危险因素。一些研究表明遗传因素可能会增加对LD的易感性。在本章中，我们讨论了目前鉴定遗传易感性因素的技术和科学方法。这些基因研究提供了人类对细胞内病原体的免疫反应的见解，并可能改善治疗和疫苗开发的策略。
Legionella pneumophila is a facultative intracellular pathogen that is an important cause of pneumonia. Although host factors that may predispose to acquisition of Legionnaire's Disease (LD) include comorbid illnesses (e.g., diabetes, chronic lung disease), age, male sex, and smoking, many individuals have no identifiable risk factors. Some studies suggest that genetic factors may enhance susceptibility to LD. In this chapter we discuss current techniques and scientific methods to identify genetic susceptibility factors. These genetic studies provide insight into the human immune response to intracellular pathogens and may improve strategies for treatment and vaccine development.