Fear of blindness in the collaborative initial glaucoma treatment study - Patterns and correlates over time
Fear of blindness in the collaborative initial glaucoma treatment study - Patterns and correlates over time
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DOI：
10.1016/j.ophtha.2007.02.014
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发表时间：
2007-12-01
期刊：
影响因子：
13.7
通讯作者：
Lichter, Paul R.
中科院分区：
文献类型：
--
作者：
Janz, Nancy K.;Wren, Patricia A.;Lichter, Paul R.
目的.本研究的目的是描述在最初的青光眼治疗合作研究的5年随访期间，失明恐惧（FOB）的患病率和与FOB相关的因素。设计图：随机对照临床试验。参与者：共607例新诊断的开角型青光眼患者从14个临床中心在美国招募。方法：患者被随机分配到初始药物治疗或初始小梁切除术。研究参与者在基线和6个月间隔接受临床检查和生活质量（QOL）评估。QOL问卷由受过训练的电话采访人员在一个集中的interviewingcenter.Main结果Measures：QOL问卷包括FOB评估，视力相关功能的措施，和一般的身体和心理健康的措施。有序逻辑回归分析被用来评估与FOB随时间推移的临床和生活质量的措施。结果：被告知青光眼诊断后，但在随机化，34%的患者报告至少有一个中等量的FOB。这一比例在5年内下降到11%。在多变量有序逻辑回归模型中，年龄较小、白色、受教育程度较低和收入较低与FOB增加相关（均P
Purpose. The objective of this study was to describe the prevalence of fear of blindness (FOB) and the factors associated with FOB during 5 years of follow-up in the Collaborative Initial Glaucoma Treatment Study. Design: Randomized controlled clinical trial.Participants: A total of 607 newly diagnosed patients with open-angle glaucoma were recruited from 14 clinical centers in the United States.Methods: Patients were assigned randomly either to initial medical therapy or initial trabeculectomy. Study participants received clinical examinations and quality-of-life (QOL) evaluations at baseline and 6-month intervals. The QOL questionnaire was administered by trained telephone interviewers at a centralized interviewing center.Main Outcome Measures: The QOL questionnaire included an assessment of FOB, measures of vision-related functioning, and measures of general physical and psychosocial well being. Ordinal logistic regression analyses were used to assess clinical and QOL measures associated with FOB over time.Results: After being told about the glaucoma diagnosis but before randomization, 34% of patients reported at least a moderate amount of FOB. This percent dropped to 11% at 5 years. In multivariable ordinal logistic regression models, younger age, being white, and having less education and a lower income were associated with increased FOB (all P