NMDA receptors are critical for unleashing consolidated auditory fear memories
NMDA receptors are critical for unleashing consolidated auditory fear memories
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DOI：
10.1038/nn1778
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发表时间：
2006-10-01
影响因子：
25
通讯作者：
Nader, Karim
中科院分区：
文献类型：
--
作者：
Ben Mamou, Cyrinne;Gamache, Karine;Nader, Karim
记忆是动态的，在回忆的时候会发生变化。在记忆过程中，将记忆恢复到不稳定状态的过程尚不清楚。我们发现，在回忆之前，杏仁核中的受体拮抗剂NMDA的存在，而不是AMPA，阻止了巩固的恐惧记忆回到不稳定状态。这些发现表明，杏仁核中的NMDA受体对于将记忆从固定状态转变为不稳定状态至关重要。
Memories are dynamic and can change when recalled. The process that returns memories to a labile state during remembering is unclear. We found that the presence of NMDA, but not AMPA, receptor antagonists in the amygdala prior to recall prevented the consolidated fear memory from returning to a labile state. These findings suggest that NMDA receptors in the amygdala are critical for transforming a memory from a fixed to a labile state.