Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome.
Omega-3 fatty acids and the genetic risk of early onset acute coronary syndrome.
复制标题
Omega-3 脂肪酸与早发急性冠状动脉综合征的遗传风险。
DOI：
10.1016/j.numecd.2014.06.001
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
L. Pilote
中科院分区：
文献类型：
--
作者：
S. S. L. Leung Yinko;G. Thanassoulis;K. Stark;M. Avgil Tsadok;J. Engert;L. Pilote
背景和目的最近的基因-环境相互作用研究表明，饮食可能影响个体对心血管风险的遗传易感性。我们评估了ω -3脂肪酸的摄入是否会影响早发性ACS患者的遗传多态性所导致的急性冠脉综合征（ACS）的风险。方法和结果我们的人群包括705名欧洲白人后裔，他们加入了GENESIS-PRAXY，这是一项多中心队列研究，研究对象是18-55岁住院的ACS患者。我们采用个案设计来研究omega-3指数（omega-3脂肪酸摄入量的有效生物标志物）与30个与ACS密切相关的单核苷酸多态性（snp）之间的相互作用。我们使用逻辑回归来评估每个SNP与omega-3指数之间的相互作用。还评估了omega-3指数与由30个snp产生的遗传风险评分之间的相互作用。所有模型都根据年龄和性别进行了调整。染色体9p21变异rs4977574携带者与低omega-3指数之间存在ACS风险增加的相互作用（OR 1.57, 95% CI 1.07-2.32,p= 0.02），但经多重检验校正后，这一相互作用并不显著。在调整后的模型中也得到了类似的结果（OR 1.55, 95% CI 1.05-2.29,p= 0.03）。我们没有观察到遗传风险评分或任何其他snp与omega-3指数之间的任何相互作用。结论omega-3脂肪酸摄入可能改变染色体9p21变异带来的早发性ACS发生的遗传风险，且需要独立复制。
Background and aimsRecent gene-environment interaction studies suggest that diet may influence an individual's genetic predisposition to cardiovascular risk. We evaluated whether omega-3 fatty acid intake may influence the risk for acute coronary syndrome (ACS) conferred by genetic polymorphisms among patients with early onset ACS.Methods and resultsOur population consisted of 705 patients of white European descent enrolled in GENESIS-PRAXY, a multicenter cohort study of patients aged 18–55 years and hospitalized with ACS. We used a case-only design to investigate interactions between the omega-3 index (a validated biomarker of omega-3 fatty acid intake) and 30 single nucleotide polymorphisms (SNPs) robustly associated with ACS. We used logistic regression to assess the interaction between each SNP and the omega-3 index. Interaction was also assessed between the omega-3 index and a genetic risk score generated from the 30 SNPs. All models were adjusted for age and sex. An interaction for increased ACS risk was found between carriers of the chromosome 9p21 variant rs4977574 and low omega-3 index (OR 1.57, 95% CI 1.07–2.32,p= 0.02), but this was not significant after correction for multiple testing. Similar results were obtained in the adjusted model (OR 1.55, 95% CI 1.05–2.29,p= 0.03). We did not observe any interaction between the genetic risk score or any of the other SNPs and the omega-3 index.ConclusionOur results suggest that omega-3 fatty acid intake may modify the genetic risk conferred by chromosome 9p21 variation in the development of early onset ACS and requires independent replication.
DOI：
10.1016/j.jvs.2004.03.014
发表时间：
2004-06
期刊：
The New England journal of medicine
影响因子：
--
作者：
J. Dwyer;H. Allayee;K. Dwyer;Jingxu Fan;Huiyun Wu;R. Mar;A. Lusis;M. Mehrabian
通讯作者：
J. Dwyer;H. Allayee;K. Dwyer;Jingxu Fan;Huiyun Wu;R. Mar;A. Lusis;M. Mehrabian
影响因子：
7.7
作者：
Gatto, NM;Campbell, UB;Ahsan, H
通讯作者：
Ahsan, H
影响因子：
4.2
作者：
Mozaffarian, Dariush;Wu, Jason H. Y.
通讯作者：
Wu, Jason H. Y.