Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: Autonomic symptom and demographic comparison
Clinical phenotype of subjects with Parkinson's disease and orthostatic hypotension: Autonomic symptom and demographic comparison
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DOI：
10.1002/mds.20996
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发表时间：
2006-11-01
影响因子：
8.6
通讯作者：
Burn, David J.
中科院分区：
文献类型：
--
作者：
Allcock, Liesl M.;Kenny, Rose Anne;Burn, David J.
本研究的目的是表征帕金森病（PD）中直立性低血压（OH）的表型关联。对159名PD患者进行了评估，包括自主症状严重程度评分、疾病特异性评分量表和体位血压反应测量。自主神经损伤的症状与病程和严重程度呈弱相关。姿势和步态不稳定（PIGD）运动表型与更严重的自主神经症状相关。80名受试者（50.3%）有OR，这些受试者年龄较大，更可能是男性，服用的多巴胺能药物剂量比没有OH的人大。有或没有OH的患者在疾病严重程度和持续时间上没有差异，症状性头晕在组间没有区别，尽管有OH的受试者比没有OH的受试者有更多的全身性自主神经损伤的症状。进行性自主神经受累可能与PD的疾病进展有关，特别是在PIGD表型的患者中，但是将OH和不OH分为两组是一种相对不敏感的方法来证明这一点。自主神经反射异常、自主神经症状和运动严重程度的纵向研究可能会澄清这些关联。(c) 2006年运动障碍协会
The objective of this study was to characterize the phenotypic associations of orthostatic hypotension (OH) in Parkinson's disease (PD). One hundred fifty-nine subjects with PD underwent assessment including autonomic symptom severity scoring, disease-specific rating scales, and measurement of postural blood pressure response. Symptoms of autonomic impairment weakly correlated with disease duration and severity. A posture and gait instability (PIGD) motor phenotype was associated with greater severity of autonomic symptoms. Eighty subjects (50.3%) had OR These subjects were older, more likely to be male, and taking larger doses of dopaminergic medications than those without OH. There was no difference in disease severity or duration between those with and those without OR Symptomatic dizziness did not distinguish between groups, although subjects with OH had more symptoms of generalized autonomic impairment than those without. Progressive autonomic involvement may be linked to disease progression in PD, particularly in patients with a PIGD phenotype, but dichotomization into groups with and without OH is a relatively insensitive method for demonstrating this. Longitudinal studies of changes in autonomic reflex abnormalities, autonomic symptom profiles, and motor severity might clarify these associations. (c) 2006 Movement Disorder Society