Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics
Highly Efficient Photosensitizers with Far-Red/Near-Infrared Aggregation-Induced Emission for In Vitro and In Vivo Cancer Theranostics
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DOI：
10.1002/adma.201802105
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发表时间：
2018-09-26
影响因子：
29.4
通讯作者：
Tang, Ben Zhong
中科院分区：
文献类型：
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作者：
Wang, Dong;Lee, Michelle M. S.;Tang, Ben Zhong
荧光成像引导的光动力疗法已经成为癌症治疗的一种很有前途的方案。然而，简便易行地制备这样一种治疗材料，以同时实现长波长的明亮发射、高性能的活性氧物种(ROS)的产生和良好的肿瘤细胞的靶向性，是非常理想的，但仍然具有挑战性。本研究通过几步反应合成了一种新型的具有聚集诱导发射(AIE)特性的远红/近红外荧光分子。这些AIE发光体具有结构简单、光稳定性好、斯托克斯位移大、发光明亮和良好的生物相容性。同时，它们的ROS产生效率极高，ROS量子产率高达90.7%，远远优于一些常用的光敏剂。重要的是，这些AIEgen能够选择性地靶向和消融正常细胞上的癌细胞，而不需要任何额外的靶向配体的帮助。与使用激光不同，其中一种抗原(MeTTPy)通过使用超低功率灯光(18 mW cm(-2))显示了显著的肿瘤靶向光动力学治疗效果。因此，这项研究不仅扩大了AIEgen的应用范围，而且为设计新一代癌症治疗药物提供了有益的见解。
Fluorescence-imaging-guided photodynamic therapy has emerged as a promising protocol for cancer theranostics. However, facile preparation of such a theranostic material for simultaneously achieving bright emission with long wavelength, high-performance reactive oxygen species (ROS) generation, and good targeting-specificity of cancer cells, is highly desirable but remains challenging. In this study, a novel type of far-red/near-infrared-emissive fluorescent molecules with aggregation-induced emission (AIE) characteristics is synthesized through a few steps reaction. These AIE luminogens (AIEgens) possess simple structures, excellent photostabilities, large Stokes shifts, bright emission, and good biocompatibilities. Meanwhile, their ROS generation is extremely efficient with up to 90.7% of ROS quantum yield, which is far superior to that of some popularly used photosensitizers. Importantly, these AIEgens are able to selectively target and ablate cancer cells over normal cells without the aid of any extra targeting ligands. Rather than using laser light, one of the presented AIEgens (MeTTPy) shows a remarkable tumor-targeting photodynamic therapeutic effect by using an ultralow-power lamp light (18 mW cm(-2)). This study thus not only extends the applications scope of AIEgens, but also offers useful insights into designing a new generation of cancer theranostics.