Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population
Serum 25-hydroxyvitamin D3 and the risk of pneumonia in an ageing general population
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DOI：
10.1136/jech-2012-202027
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发表时间：
2013-06-01
影响因子：
6.3
通讯作者：
Tuomainen, Tomi-Pekka
中科院分区：
文献类型：
--
作者：
Aregbesola, Alex;Voutilainen, Sari;Tuomainen, Tomi-Pekka
背景 维生素 D 在感染防御和免疫系统中发挥作用。因此，我们研究了血清 25-羟基维生素 D-3 (25(OH)D-3) 对芬兰东部老龄化普通人群发生住院肺炎风险的影响。 方法 研究人群包括 723 名男性和 698 名女性，年龄为 53-73 岁，来自前瞻性人群 Kuopio 缺血性心脏病危险因素研究，他们在 1998-2001 年基线时没有肺炎、其他肺部疾病和癌症。通过与出院登记册的记录链接来收集导致住院的肺炎事件。血清维生素 D 状态测定为 25(OH)D-3 浓度。采用Cox比例风险回归模型分析血清25(OH)D-3对肺炎发生风险的影响。结果研究人群血清25(OH)D-3浓度的平均(SD)为43.5(17.8)nmol/l。在平均 9.8 年的随访期间，73 名受试者至少有过一次因肺炎住院的经历。经过多变量调整后，血清 25(OH)D-3 最低三分位数的受试者患肺炎的风险比最高三分位数的受试者高 2.6 倍（95% CI 1.4 至 5.0，三分位数间 p 趋势 = 0.005）。即使在调整血清 25-羟基维生素 D-3 的决定因素后，这一显着结果仍然存在。 结论 这些数据表明，血清 25(OH)D-3 浓度对一般老龄化人群中发生肺炎的风险具有反向影响。
Background Vitamin D has been suggested to have a role in infection defence and on the immune system. We therefore investigated the effect of serum 25-hydroxyvitamin D-3 (25(OH)D-3) on the risk of incident hospitalised pneumonia in an ageing general population in eastern Finland.Methods The study population included 723 men and 698 women aged 53-73 years from the prospective population-based Kuopio Ischemic Heart Disease Risk Factor study who were free of pneumonia, other pulmonary diseases and cancer at baseline in 1998-2001. Incident pneumonia episodes leading to hospitalisation were collected by record linkage to the hospital discharge register. The serum vitamin D status was assayed as 25(OH)D-3 concentration. Cox proportional hazards regression models were used to analyse the effect of serum 25(OH)D-3 on the risk of incident pneumonia.Results The mean (SD) serum 25(OH)D-3 concentration of the study population was 43.5 (17.8) nmol/l. 73 subjects had at least one hospitalisation episode due to pneumonia during an average follow-up of 9.8 years. After multivariable adjustments, the subjects in the lowest serum 25(OH)D-3 tertile had a 2.6-fold (95% CI 1.4 to 5.0, p trend across tertiles=0.005) higher risk of developing pneumonia compared with the subjects in the highest tertile. This significant result remained even after adjustment for the determinants of serum 25-hydroxyvitamin D-3.Conclusions These data suggest an inverse effect of serum 25(OH)D-3 concentration on the risk of incident pneumonia in the general ageing population.