Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection.
Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection.
复制标题
DOI：
10.1111/j.1567-1364.2010.00632.x
复制
发表时间：
2010-08-01
影响因子：
3.2
通讯作者：
Jabra-Rizk MA
中科院分区：
文献类型：
--
作者：
Peters BM;Zhu J;Fidel PL Jr;Scheper MA;Hackett W;El Shaye S;Jabra-Rizk MA
The oral cavity is a primary target for opportunistic infections, particularly oral candidiasis caused by Candida albicans. A commensal fungus commonly colonizing mucosal surfaces, under conditions of immune dysfunction C. albicans can become a pathogen causing recurrent infections. Yet, the role of host oral innate immunity in the development of candidiasis is not fully elucidated. Specifically, the host salivary antimicrobial peptide histatin-5 (Hst-5) has been proposed to play a protective role in the oral cavity against C. albicans. However, investigations demonstrating its efficacy oral tissue have been lacking. To that end in this study, an ex vivo murine model of infection was developed. Viable C. albicans counts and histopathological analyses demonstrated a significant protective effect for Hst-5 on mouse oral tissue against C. albicans. More importantly, host saliva exerted a comparable anti-candidal effect. However, this effect was neutralized upon treatment of saliva with proteases and C. albicans, previously shown to degrade Hst-5, indicating that Hst-5 is likely the salivary component responsible for the observed protection. Combined, the findings from this study demonstrate for the first time the efficacy of salivary Hst-5 in protecting host tissue against C. albicans infection, thereby affirming the therapeutic potential of this natural host peptide.
登录
查看更多内容
影响因子：
3.1
作者：
Villar, C. C.;Kashleva, H.;Dongari-Bagtzoglou, A.
通讯作者：
Dongari-Bagtzoglou, A.
DOI：
10.1023/a:1026572128004
发表时间：
2000-08-01
影响因子：
2.6
作者：
van't Hof, W;Reijnders, IM;Amerongen, AVN
通讯作者：
Amerongen, AVN
影响因子：
4.1
作者：
Helmerhorst, EJ;VantHof, W;Amerongen, AVN
通讯作者：
Amerongen, AVN
影响因子：
3.1
作者：
Koshlukova, SE;Araujo, MWB;Edgerton, M
通讯作者：
Edgerton, M
影响因子：
3.7
作者：
Meiller TF;Hube B;Schild L;Shirtliff ME;Scheper MA;Winkler R;Ton A;Jabra-Rizk MA
通讯作者：
Jabra-Rizk MA