Regiodivergent Stereoselective Access to Fused Alkylideneazetidines.
Regiodivergent Stereoselective Access to Fused Alkylideneazetidines.
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DOI：
10.1021/acs.joc.7b02786
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发表时间：
2018-01
期刊：
影响因子：
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通讯作者：
Arif Music;A. Baumann;Michael Eisold;Dorian Didier
中科院分区：
文献类型：
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作者：
Arif Music;A. Baumann;Michael Eisold;Dorian Didier
在2 H-氮杂环丁烷合成的推广和简化方面取得进展后，通过中间体形成前所未有的乙烯基氮杂环丁烷结构，设计了一种区域发散的方法来合成稠合的2-和3-亚烷基氮杂环丁烷。简明的序列，后者描述了一个预期的不饱和稠环系统分离，具有非常高的产率和区域和立体选择性的[4 + 2]环加成。
Following recent advances in the generalization and simplification of 2H-azetine synthesis, a regiodivergent approach to fused 2- and 3-alkylideneazetines was designed via the intermediate formation of unprecedented vinylazetine structures. Concise sequences to the latter are described from which an expected unsaturated fused ring system was isolated with very high yields and regio- and stereoselectivities by [4 + 2] cycloadditions.