Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol-induced myocardial infarction in rats
Pretreatment with alcoholic extract of Crataegus oxycantha (AEC) activates mitochondrial protection during isoproterenol-induced myocardial infarction in rats
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DOI：
10.1007/s11010-006-9218-3
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发表时间：
2006-11-01
影响因子：
4.3
通讯作者：
Devaraj, S. Niranjali
中科院分区：
文献类型：
--
作者：
Jayalakshmi, R.;Thirupurasundari, C. J.;Devaraj, S. Niranjali
山楂在草药和顺势疗法中用作强心剂。本研究旨在观察尖吻山楂醇提物（AEC）对实验性心肌梗死大鼠心肌线粒体功能的影响。雄性白化病大鼠（150-200 g）经口给予AEC，剂量为0.5 ml/100 g体重/天，持续30天。实验期结束时，每隔24小时对动物给予异丙肾上腺素（85 mg/kg体重，皮下注射），持续2天。48小时后，麻醉并处死大鼠。将心脏均质化用于生化和电子显微镜分析。AEC预处理可维持大鼠心肌线粒体抗氧化状态，防止异丙肾上腺素引起的线粒体脂质过氧化损伤和Kreb循环酶活性下降。
Crataegus oxycantha (hawthorn) is used in herbal and homeopathic medicine as a cardiotonic. The present study was done to investigate the effect of the alcoholic extract of Crataegus oxycantha (AEC) on mitochondrial function during experimentally induced myocardial infarction in rat. AEC was administered orally to male albino rats (150-200 g), at a dosage of 0.5 ml/100 g body weight/day, for 30 days. At the end of the experimental period, the animals were administered isoproterenol (85 mg/kg body weight, s.c) for 2 days at an interval of 24 h. After 48 h, the rats were anaesthetized and sacrificed. The hearts were homogenized for biochemical and electron microscopic analysis. AEC pretreatment maintained mitochondrial antioxidant status, prevented mitochondrial lipid peroxidative damage and decrease in Kreb's cycle enzymes induced by isoproterenol in rat heart.