Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant
Recent progress of fully synthetic carbohydrate-based vaccine using TLR agonist as build-in adjuvant
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TLR激动剂作为内置佐剂的全合成碳水化合物疫苗的最新进展
DOI：
10.1016/j.cclet.2017.09.047
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发表时间：
2018
影响因子：
9.1
通讯作者：
Zhimeng Wu
中科院分区：
文献类型：
--
作者：
Zhifang Zhou;Han Lin;chen Li;Zhimeng Wu
全合成疫苗是将一种或多种分子抗原结合到具有明确化学结构的合成载体上，是开发基于碳水化合物的抗肿瘤和病原体疫苗的一个新方向。Toll样受体（TLR）激动剂具有刺激免疫应答的能力，已被广泛研究并被用作构建全合成疫苗的内置佐剂。特别是，近年来在用TLR 1/2、TLR 2/6和TLR 4的激动剂和肿瘤相关碳水化合物抗原（TACA）构建的疫苗的开发方面取得了显著进展。这些二组分、三组分或多组分候选疫苗显示出有吸引力的免疫学特性。本文综述了近年来全合成糖抗原疫苗的研究进展，重点介绍了糖抗原的构效关系，为今后的疫苗设计和免疫治疗提供了基础。
Fully synthetic vaccine, in which one or multi-molecular antigens are conjugated to a synthetic carrier with well-defined chemical structure, is a new direction to develop carbohydrate-based vaccine against cancer and pathogens. Toll like receptor (TLR) agonists with the ability to stimulate immune response have been widely investigated and been applied as build-in adjuvants to construct fully synthetic vaccines. In particular, remarkable progress has been achieved in recent years in the development of vaccines constructed with the agonists of TLR1/2, TLR2/6 and TLR4 and tumor-associated carbohydrate antigens (TACAs). These di-, tri- or multi-component vaccine candidates showed attractive immunological properties. This review highlights recent advances in developing full synthetic carbohydrate antigen based vaccines, with an emphasis on the structure-activity relationships that provide a primary basis for future vaccine design and immunotherapy developing.
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影响因子：
7.8
作者：
Guo, Zhongwu;Wang, Qianli
通讯作者：
Wang, Qianli
影响因子：
--
作者：
Brendan L Wilkinson;Stephanie L Day;R. Chapman;S. Perrier;V. Apostolopoulos;R. Payne
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
4.3
作者：
Cai, Hui;Huang, Zhi-Hua;Li, Yan-Mei
通讯作者：
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