EFFECTS OF 5-FLUOROURACIL ON THE THIAMIN STATUS OF ADULT FEMALE RATS
EFFECTS OF 5-FLUOROURACIL ON THE THIAMIN STATUS OF ADULT FEMALE RATS
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DOI：
10.1159/000237825
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发表时间：
1979-01-01
期刊：
影响因子：
3.3
通讯作者：
DICKERSON, JWT
中科院分区：
文献类型：
--
作者：
BASU, TK;AKSOY, M;DICKERSON, JWT
研究了5-氟尿嘧啶（一种抗癌抗代谢物）对正常成年雌性大鼠体内硫胺素水平的影响。与配对喂养的对照动物相比，连续3天每天使用细胞毒性药物预处理动物，肝脏中硫胺素浓度显著降低，硫胺素依赖性转酮醇酶活性降低，全血中硫胺素焦磷酸（TPP）刺激作用增强。体外5-氟尿嘧啶也能提高转酮醇酶活性的TPP效应。此外，在补充了大剂量维生素的动物中，5-氟尿嘧啶治疗导致肝脏和脾脏浓度下降，而不影响尿中硫胺素的排泄水平。给予与人体治疗剂量相当的剂量，也会导致类似的TPP效应增加。5-氟尿嘧啶治疗可能通过增加硫胺素的利用或分解与硫胺素缺乏症有关。
The effect of 5-fluorouracil [an anticancer antimetabolite] on the thiamine status of normal female adult rats was investigated. Pretreatment of the animals with the cytotoxic drug daily for 3 successive days resulted in a significant decrease in hepatic concentrations of thiamine concomitant with a decrease in thiamine-dependent transketolase enzyme activity and an increase in thiamine-pyrophosphate (TPP)-stimulating effect in whole blood when compared with those of pair-fed control animals. The TPP effect of transketolase enzyme activity was also increased by 5-fluorouracil in vitro. Furthermore, the treatment with 5-fluorouracil resulted in decreased liver and spleen concentrations without affecting the urinary excretory levels of thiamine in animals supplemented with large doses of the vitamin. Giving a dose comparable to a human therapeutic dose caused a similar increase in the TPP effect. Treatment with 5-fluorouracil may be associated with thiamine deficiency by increasing the utilization or the breakdown of thiamine.