Excavatoids G-K, New 8,17-Epoxybriaranes from the Cultured Octocoral Briareum excavatum (Briareidae)
Excavatoids G-K, New 8,17-Epoxybriaranes from the Cultured Octocoral Briareum excavatum (Briareidae)
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DOI：
10.1246/bcsj.20090306
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发表时间：
2010-05-15
影响因子：
4
通讯作者：
Chen, Jih-Jung
中科院分区：
文献类型：
--
作者：
Sung, Ping-Jyun;Chen, Bo-Yuan;Chen, Jih-Jung
对人工养殖的八珊瑚进行化学研究，分离得到5个新的8，17-环氧桥烷二萜类化合物G-K(1-5)。用波谱方法确定了化合物1-5的结构，并用单晶X-射线衍射法进一步确证了化合物的结构。描述了这些代谢物对不同肿瘤细胞系的细胞毒性。研究发现，类空泡蛋白I(3)对中性粒细胞释放弹性蛋白酶和产生超氧阴离子有轻微的抑制作用。
Chemical investigations on the cultured octocoral Briareum excavatum have led to the isolation of five new 8,17-epoxybriarane diterpenoids, excavatoids G-K (1-5). The structures of briaranes 1-5 were determined on the basis of spectroscopic methods and the structure of 1 was further confirmed by a single-crystal X-ray diffraction analysis. Cytotoxicity of these metabolites toward various tumor cell lines is described. Excavatoid I (3) was found to show mild inhibitory effects on elastase release and superoxide anion generation by human neutrophils.