Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli
Low level of galacto-oligosaccharide in infant formula stimulates growth of intestinal Bifidobacteria and Lactobacilli
复制标题
DOI：
10.3748/wjg.14.6564
复制
发表时间：
2008-11-14
影响因子：
4.3
通讯作者：
Zhou, Xiao-Yu
中科院分区：
文献类型：
--
作者：
Ben, Xiao-Ming;Li, Juan;Zhou, Xiao-Yu
目的：研究低聚半乳糖（0.24 g/100 mL）对婴幼儿肠道菌群（双歧杆菌、乳酸杆菌和大肠杆菌）的影响。大肠杆菌）和发酵特性的足月婴儿，比较人乳和标准的婴儿配方奶粉没有GOS。方法：足月婴儿（n = 371），在中国的三家医院进行了这项研究。所有婴儿开始母乳喂养。那些在出生后4周内改为配方奶粉喂养的婴儿被随机分配到两个配方奶粉组中的一个。在3个月的随访期内记录招募婴儿的生长和粪便特征以及发生的副作用。从招募的婴儿亚群中收集粪便样本用于肠道细菌分析结果：3个月后，与不含GOS的配方奶粉喂养的婴儿相比，喂养GOS配方奶粉或母乳的婴儿肠道双歧杆菌、乳酸杆菌、乙酸和粪便频率显著增加，粪便pH值降低。在GOS配方奶粉组和人乳组之间没有观察到显著差异。结论：婴儿配方奶粉中添加低水平的GOS（0.24g/100 mL）可改善大便次数，降低粪便pH值，刺激肠道双歧杆菌和乳酸杆菌，与母乳喂养的婴儿相似。(c)2008年，WJG出版社。All rights reserved.
AIM: To investigate the effect of a new infant formula supplemented with a low level (0.24 g/100 mL) of galacto-oligosaccharide (GOS) on intestinal micro-flora (Bifidobacteria, Lactobacilli and E. coli) and fermentation characteristics in term infants, compared with human milk and a standard infant formula without GOS.METHODS: Term infants (n = 371) were approached in this study in three hospitals of China. All infants started breast-feeding. Those who changed to formula-feeding within 4 wk after birth were randomly assigned to one of the two formula groups. Growth and stool characteristics, and side effects that occurred in recruited infants were recorded in a 3-mo follow-up period. Fecal samples were collected from a subpopulation of recruited infants for analysis of intestinal bacteria (culture technique), acetic acid (gas chromatography) and pH (indicator strip).RESULTS: After 3 mo, the intestinal Bifidobacteria Lactobacilli, acetic acid and stool frequency were significantly increased, and fecal pH was decreased in infants fed with the GOS-formula or human milk, compared with those fed with the formula without GOS. No significant differences were observed between the GOS formula and human milk groups. Supplementation with GOS did not influence the incidence of crying, regurgitation and vomiting.CONCLUSION: A low level of GOS (0.24 g/100 mL) in infant formula can improve stool frequency, decrease fecal pH, and stimulate intestinal Bifidobacteria and Lactobacilli as in those fed with human milk. (c) 2008 The WJG Press. All rights reserved.