Directing reprogramming to pluripotency by transcription factors
Directing reprogramming to pluripotency by transcription factors
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DOI：
10.1016/j.gde.2012.07.001
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发表时间：
2012-10-01
影响因子：
4
通讯作者：
Schoeler, Hans R.
中科院分区：
文献类型：
--
作者：
Adachi, Kenjiro;Schoeler, Hans R.
多能状态由特异性表达的转录因子控制，与更广泛表达的转录因子一起形成高度互连的调控网络。转录网络表现出层次结构，少数转录因子在维持多能性和控制更多的辅助转录因子中发挥重要作用。当包含Oct4、Sox 2、Klf 4和Myc的主转录因子组在体细胞中异位表达时，转录网络被推动以支持多能状态的方式组织自身。这些转录因子在重编程过程中通过影响局部染色质状态而在重塑基因表达中发挥不同但相互依赖的作用。
The pluripotent state is governed by specifically expressed transcription factors forming a highly interconnected regulatory network in concert with more widely expressed transcription factors. The transcriptional network exhibits a hierarchical structure, with a small number of transcription factors playing an essential role in maintaining pluripotency and controlling the more numerous auxiliary transcription factors. When the set of master transcription factors comprising Oct4, Sox2, Klf4, and Myc is expressed ectopically in somatic cells, the transcriptional network is propelled to organize itself in such a way as to support a pluripotent state. These transcription factors play distinct but interdependent roles in remodeling gene expression by influencing the local chromatin status during reprogramming.