Thymus changes in anti-MuSK-positive and -negative myasthenia gravis
Thymus changes in anti-MuSK-positive and -negative myasthenia gravis
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DOI：
10.1212/01.wnl.0000150587.71497.b6
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发表时间：
2005-02-08
期刊：
影响因子：
9.9
通讯作者：
Evoli, A
中科院分区：
文献类型：
--
作者：
Lauriola, L;Ranelletti, F;Evoli, A
对32例抗乙酰胆碱受体（AChR）阴性的重症肌无力患者（12例有和20例无肌肉特异性激酶（MuSK）抗体）胸腺的形态学结果与30例AChR阳性受试者进行了比较。与AChR阳性患者胸腺增生性改变的高频率相反，MuSK阳性受试者的组织学改变是最小的，反对胸腺内疾病的发病机制。由于在35%的MuSK阴性患者中观察到增生性变化，因此其中一些病例可能涉及胸腺。
Morphologic findings of thymuses from 32 anti-acetylcholine receptor (AChR)-negative myasthenia gravis patients, 12 with and 20 without antibodies against the muscle-specific kinase ( MuSK), were compared with those from 30 AChR-positive subjects. In contrast with the high frequency of thymic hyperplastic changes in AChR-positive patients, in MuSK-positive subjects histologic alterations were minimal, arguing against an intrathymic disease pathogenesis. Since hyperplastic changes were seen in 35% of MuSK-negative patients, the thymus could be involved in some of these cases.