Integrating complex host-pathogen immune environments into S. aureus vaccine studies.
Integrating complex host-pathogen immune environments into S. aureus vaccine studies.
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将复杂的宿主 - 病原体免疫环境整合到金黄色葡萄球菌疫苗研究中。
DOI：
10.1016/j.chembiol.2022.04.003
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发表时间：
2022-05-19
影响因子：
8.6
通讯作者：
Liu, George Y.
中科院分区：
文献类型：
--
作者：
Tsai, Chih-Ming;Hajam, Irshad A.;Caldera, J. R.;Liu, George Y.
Staphylococcus aureus (SA) is a leading cause of bacterial infection and antibiotic resistance globally. Therefore, development of an effective vaccine has been a major goal of the SA field for the past decades. With the wealth of understanding of pathogenesis, the failure of all SA vaccine trials has been a surprise. We argue that experimental SA vaccines have not worked because vaccines have been studied in naïve laboratory animals, whereas clinical vaccine efficacy is tested in immune environments reprogrammed by SA. Here, we review the failed SA vaccines that have seemingly defied all principles of vaccinology. We describe major SA evasion strategies and suggest that they reshape the immune environment in a way that makes vaccines prone to failures. We propose that appropriate integration of concepts of host-pathogen interaction into vaccine study designs could lead to insight critical for the development of an effective SA vaccine. The failure of all S. aureus vaccine trials has been a conundrum. Tsai et al. propose that staphylococcal vaccine failures result from underappreciation of how the pathogen preprograms the host immune system for vaccine failures. Understanding S. aureus modulation of vaccine responses may hold the key to developing successful vaccines.
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