Chronic kidney disease and cardiovascular disease in a general Japanese population: The Hisayama Study
Chronic kidney disease and cardiovascular disease in a general Japanese population: The Hisayama Study
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DOI：
10.1111/j.1523-1755.2005.00397.x
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发表时间：
2005-07-01
影响因子：
19.6
通讯作者：
Iida, M
中科院分区：
文献类型：
--
作者：
Ninomiya, T;Kiyohara, Y;Iida, M
背景。慢性肾脏病已被证明是高危人群心血管疾病的独立危险因素。然而，这种关系在社区人群中尚无定论。方法。为了澄清这个问题，我们对 2634 名年龄在 40 岁以上、无心血管疾病的社区居民进行了为期 12 年的跟踪研究，研究了慢性肾脏病与心血管疾病发病率之间的关系。结果。在随访期间，99名受试者（56名男性和43名女性）患有冠心病，137名受试者（60名男性和77名女性）患有缺血性中风，60名受试者（26名男性和34名女性）患有出血性中风。在男性中，患有慢性肾病的受试者的年龄调整冠心病发病率显着高于无慢性肾病的受试者（每1000人年6.2 vs 2.9）（P < 0.05），但在缺血性中风中没有观察到这种关系。相比之下，在女性中，患有慢性肾病的受试者中缺血性卒中的年龄调整发病率显着高于无慢性肾病的受试者（3.4 vs. 2.5）（P < 0.05），而冠心病的发病率则不然。未发现慢性肾病与出血性中风的发生率相关。多变量分析中，即使在调整传统和非传统心血管疾病危险因素后，发现慢性肾脏病是男性发生冠心病的独立危险因素[风险比（HR），2.26； 95% CI，1.06-4.79]，以及女性缺血性卒中的发生率（HR，1.91；95% CI，1.15-3.15）。结论。我们的研究结果表明，慢性肾脏疾病是日本普通人群发生心血管疾病的独立危险因素。
Background. Chronic kidney disease has been shown to be an independent risk factor for cardiovascular disease in high-risk populations. However, this relationship is inconclusive in community-based populations.Methods. To clarify this issue, we followed 2634 community-dwelling individuals without cardiovascular disease, aged 40 years or older, for 12 years and examined the relationship between chronic kidney disease and the incidence of cardiovascular disease.Results. During the follow-up period, 99 subjects (56 men and 43 women) experienced coronary heart disease, 137 subjects (60 men and 77 women) ischemic stroke, and 60 subjects (26 men and 34 women) hemorrhagic stroke. In men, the age-adjusted incidence of coronary heart disease was significantly higher in subjects with chronic kidney disease than in those without it (6.2 vs. 2.9 per 1000 person-years) (P < 0.05), but such a relationship was not observed with ischemic stroke. In contrast, in women, the age-adjusted incidence of ischemic stroke was significantly higher in subjects with chronic kidney disease than in those without it (3.4 vs. 2.5) (P < 0.05), while that of coronary heart disease was not. Chronic kidney disease was not found to be associated with the incidence of hemorrhagic stroke. In multivariate analysis, even after adjustments for traditional and nontraditional cardiovascular disease risk factors, chronic kidney disease was found to be an independent risk factor for the occurrence of coronary heart disease in men [hazard ratio (HR), 2.26; 95% CI, 1.06-4.79], and for the occurrence of ischemic stroke in women (HR, 1.91; 95% CI, 1.15-3.15).Conclusion. Our findings suggest that chronic kidney disease is an independent risk factor for the occurrence of cardiovascular disease in the general Japanese population.