CHOLESTEROL SOLUBILITY IN ORGANIC-SOLVENTS
CHOLESTEROL SOLUBILITY IN ORGANIC-SOLVENTS
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DOI：
10.1002/jps.2600680908
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发表时间：
1979-01-01
影响因子：
3.8
通讯作者：
HOFMANN, AF
中科院分区：
文献类型：
--
作者：
FLYNN, GL;SHAH, Y;HOFMANN, AF
37度。胆固醇在50多种溶剂中的溶解度，包括同系物正构醇通过十二醇和同系物乙酸乙酯通过十一酸和37度。报道了β-谷甾醇在正构烷醇中通过正十二醇的溶解度。胆固醇在7度、17度和27度的溶解度数据。在酒精系列中也得到了。这些测量允许计算胆固醇在烷醇中的溶解热，范围从7.5千卡(甲醇)到4.3千卡(癸醇)，并随着烷醇链长的增加而趋于下降，尽管是不规则的。在所有这些系列中，两种溶质的最大溶解度都出现在6到7的链长之间。在所有4个温度下，胆固醇在烷醇中的溶解度都出现了令人惊讶的不规则的奇偶交替的溶解度模式。这种模式可能是由于溶剂引起的结晶变化，推测是通过C10在每种烷醇溶剂中形成溶剂。溶解度研究筛选了溶解胆固醇和胆固醇结石的溶剂。进行了一些有限溶解实验，结果表明，溶解速率与测定的有机溶剂的溶解度直接相关。胶束胆盐溶液的溶解行为不同于胶束胆盐溶液，胶束胆盐溶液的溶解行为由显著的界面势垒控制动力学。
The 37.degree. cholesterol solubilities in over 50 solvents, including the homologous n-alkanols through dodecanol and homologous ethyl carboxylates through the undecanoate and the 37.degree. .beta.-sitosterol solubilities in the n-alkanols through decanol are reported. Solubility data for cholesterol at 7, 17 and 27.degree. in the alcohol series were also obtained. These measurements allowed the calculation of heats of solution for cholesterol in the alkanols, which range from 7.5 kcal for methanol to 4.3 kcal for decanol and which tend to decrease, although irregularly, with increasing alkanol chain length. A solubility maximum in all of these series for both solutes was observed between a chain length of 6 and 7. A surprisingly irregular, odd-even alternating solubility pattern was noted for cholesterol in the alkanols at all 4 temperatures. This pattern was probably due to solvent-induced crystalline changes, presumably solvate formation, in each alkanol solvent through C10. The solubility studies screened solvents for their utility in dissolving cholesterol and cholesterol gallstones. Some limited dissolution experiments were performed, which indicated that the solution rate is directly related to the measured solubility in organic solvents. The dissolution behavior is different from micellar bile salt solutions, in which a significant interfacial barrier controls kinetics.