The role of caveolae in endothelial dysfunction.
The role of caveolae in endothelial dysfunction.
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小凹在内皮功能障碍中的作用。
DOI：
10.1515/mr-2021-0005
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发表时间：
2021-10
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小窝是内皮细胞中大量存在的细胞表面质膜内陷，在调节胆固醇稳态、一氧化氮产生和信号转导等多种细胞过程中起着关键作用。内皮小窝作为一个膜平台，用于与内皮一氧化氮合酶、ATP合酶β和整合素相关的信号事件的区室化、调节和整合，这些信号事件参与内皮功能障碍和相关心血管疾病（如动脉粥样硬化和高血压）的调节。此外，细胞膜上的这些动态微区受到各种细胞外刺激的调节，包括胆固醇和流动剪切应力。在这篇简短的综述中，我们总结了最近的研究结果以及我们在过去二十年的工作基础上，在内皮功能的编排小窝的关键作用。
Caveolae, the specialized cell-surface plasma membrane invaginations which are abundant in endothelial cells, play critical roles in regulating various cellular processes, including cholesterol homeostasis, nitric oxide production, and signal transduction. Endothelial caveolae serve as a membrane platform for compartmentalization, modulation, and integration of signal events associated with endothelial nitric oxide synthase, ATP synthase β, and integrins, which are involved in the regulation of endothelial dysfunction and related cardiovascular diseases, such as atherosclerosis and hypertension. Furthermore, these dynamic microdomains on cell membrane are modulated by various extracellular stimuli, including cholesterol and flow shear stress. In this brief review, we summarize the critical roles of caveolae in the orchestration of endothelial function based on recent findings as well as our work over the past two decades.