Eukaryotic translation initiation factors as promising targets in cancer therapy.
Eukaryotic translation initiation factors as promising targets in cancer therapy.
复制标题
真核翻译起始因子作为癌症治疗的有希望的靶标
DOI：
10.1186/s12964-020-00607-9
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发表时间：
2020-11-04
期刊：
影响因子：
--
通讯作者：
Xu T
中科院分区：
文献类型：
--
作者：
Hao P;Yu J;Ward R;Liu Y;Hao Q;An S;Xu T
真核细胞中信使RNA（mRNA）翻译的调控是基因表达的关键，主要发生在起始阶段，受真核起始因子（eIFs）的调控。eIF是mRNA翻译的基础，因此作为几种信号传导途径的主要靶标来调节基因表达。mRNA表达失调是肿瘤发生的一个共同特征，在许多肿瘤中检测到由上游信号通路触发的eIF复合物的异常活性，导致编码与肿瘤发生、转移或抗癌药物抗性相关的蛋白的mRNA的选择性翻译，并使eIF成为各种类型癌症的有希望的治疗靶点。在这里，我们简要概述了我们目前对eIFs生物学的理解，主要集中在几个信号通路对其功能的影响，并讨论了它们对肿瘤生长的启动和进展的贡献。此外，还概述了针对癌症治疗的翻译机制成分开发药物的进展。视频摘要
The regulation of the translation of messenger RNA (mRNA) in eukaryotic cells is critical for gene expression, and occurs principally at the initiation phase which is mainly regulated by eukaryotic initiation factors (eIFs). eIFs are fundamental for the translation of mRNA and as such act as the primary targets of several signaling pathways to regulate gene expression. Mis-regulated mRNA expression is a common feature of tumorigenesis and the abnormal activity of eIF complexes triggered by upstream signaling pathways is detected in many tumors, leading to the selective translation of mRNA encoding proteins involved in tumorigenesis, metastasis, or resistance to anti-cancer drugs, and making eIFs a promising therapeutic target for various types of cancers. Here, we briefly outline our current understanding of the biology of eIFs, mainly focusing on the effects of several signaling pathways upon their functions and discuss their contributions to the initiation and progression of tumor growth. An overview of the progress in developing agents targeting the components of translation machinery for cancer treatment is also provided.Video abstract
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DOI：
10.1097/jto.0b013e31819a5767
发表时间：
2009-04
期刊：
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
影响因子：
--
作者：
Cappuzzo F;Varella-Garcia M;Rossi E;Gajapathy S;Valente M;Drabkin H;Gemmill R
通讯作者：
Gemmill R
DOI：
10.1073/pnas.0504249102
发表时间：
2005-07-26
影响因子：
11.1
作者：
Bordeleau, ME;Matthews, J;Pelletier, J
通讯作者：
Pelletier, J
DOI：
10.1073/pnas.95.25.15078
发表时间：
1998-12-08
影响因子：
11.1
作者：
Angenstein, F;Greenough, WT;Weiler, IJ
通讯作者：
Weiler, IJ
影响因子：
16
作者：
Binda, Matteo;Peli-Gulli, Marie-Pierre;De Virgilio, Claudio
通讯作者：
De Virgilio, Claudio
影响因子：
9.8
作者：
Brady LK;Wang H;Radens CM;Bi Y;Radovich M;Maity A;Ivan C;Ivan M;Barash Y;Koumenis C
通讯作者：
Koumenis C