Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children
Perinatal and early postnatal risk factors for malignant brain tumours in New South Wales children
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新南威尔士州儿童恶性脑瘤的围产期和产后早期危险因素
DOI：
10.1002/ijc.2910560104
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发表时间：
2007
影响因子：
6.4
通讯作者：
P. Boyle
中科院分区：
文献类型：
--
作者：
M. Mccredie;P. Maisonneuve;P. Boyle
1988年至1990年期间，在新南威尔士州沿海城市（包括悉尼、卧龙岗和纽卡斯尔）对1985-1989年诊断的0 - 14岁儿童原发性恶性脑肿瘤事件进行了一项基于人群的病例对照研究。采用结构式问卷对82例病例和164例对照儿童的母亲进行了个人访谈。在检查的假设中，有与以下因素相关的假设：N-亚硝基化合物（来源包括饮食、假人、药物、烟草烟雾）;与婴儿出生相关的因素;头部创伤;辐射（通过电热毯或水床进行的X射线和电磁辐射）。报告的曾经使用假人增加了儿童脑肿瘤的风险（OR = 2.9，95% CI 1.6 - 5.4），尽管似乎没有任何一致的迹象表明风险随着报告的使用水平的增加而增加。与从未使用过假人的儿童相比，在生命的第一年中使用假人的类别最多为“每天或晚上不超过1小时”，“每天或晚上几个小时”和“白天或晚上大部分时间”，其统计学显著优势比分别为2.6，3.4和2.7。儿童在一岁前食用水果似乎具有保护作用。没有发现儿童脑肿瘤与出生体重，作为第一个出生的孩子，或与孩子出生有关的因素之间的关联;头部受伤;暴露于X射线;与马接触，或生活在农场;在孩子一生中对房屋进行杀虫剂处理;或暴露于燃烧的熏香。© 1994 Wiley利斯公司
A population‐based case‐control study of incident primary malignant brain tumours diagnosed during 1985–1989 in children aged 0 to 14 years was carried out in the coastal conurbation of New South Wales comprising Sydney, Wollon‐gong and Newcastle in the period 1988 to 1990. Personal interviews were conducted using a structured questionnaire with mothers of 82 cases and 164 control children individually matched to the cases by sex and age. Among the hypotheses examined were those related to: N‐nitroso compounds (sources included diet, dummies, medications, tobacco smoke); factors associated with the birth of the child; trauma to the head; and irradiation (X‐rays and electromagnetic radiation through electric blankets or water beds). Reported ever‐use of a dummy increased the risk of childhood brain tumours (OR = 2.9, 95% CI 1.6 to 5.4), although there did not appear to be any consistent indication of rising risk with reported increased levels of use. Compared with children who had never used a dummy, categories of use during the first year of life of a maximum of “no more than I hour per day or night”, “several hours per day or night”, and “most of the day or night” had statistically significant odds ratios of 2.6, 3.4, and 2.7 respectively. Consumption of fruit by the child before the age of one appeared to be protective. No association was found between childhood brain tumours and birth weight, being the first‐born child, or factors linked with the child's birth; head injuries; exposure to X‐rays; contact with horses, or living on a farm; pesticide treatment of the house during the child's lifetime; or exposure to burning incense. © 1994 Wiley‐Liss, Inc.