Cellular characterization of the peritumoral edema zone in malignant brain tumors
Cellular characterization of the peritumoral edema zone in malignant brain tumors
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DOI：
10.1111/j.1349-7006.2009.01259.x
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发表时间：
2009-10-01
期刊：
影响因子：
5.7
通讯作者：
Eyuepoglu, Ilker Y.
中科院分区：
文献类型：
--
作者：
Engelhorn, Tobias;Savaskan, Nic E.;Eyuepoglu, Ilker Y.
脑水肿是人类恶性脑肿瘤的标志，并有助于脑肿瘤患者的临床过程和结果。所谓的病灶周围水肿或脑肿胀在T2加权MR扫描中表现为围绕大块肿瘤的高强度区域。这种增加流体吸引力的机制和微环境的细胞组成仅部分了解。在这项研究中，我们专注于成像原位植入的胶质瘤在啮齿类动物的病灶周围水肿和相关的病灶周围水肿与免疫组化标记。我们发现，病灶周围水肿区域不仅包括肿瘤浸润区，而且还与肿瘤块周围胶质细胞酸性蛋白（GFAP）和水通道蛋白-4表达增加有关。此外，大量表达CD 11b和巨噬细胞迁移抑制因子（MIF）的活化小胶质细胞在肿瘤边缘聚集。因此，病灶周围水肿的区域主要由活脑组织的反应性变化主导。这些数据证实，在T2加权MR扫描中识别的病灶周围水肿的特征在于胶质细胞分布和标志物表达的改变，形成炎性肿瘤微环境。（Cancer Sci 2009; 100：1856-1862）。
Brain edema is a hallmark of human malignant brain tumors and contributes to the clinical course and outcome of brain tumor patients. The so-called perifocal edema or brain swelling imposes in T2-weighted MR scans as high intensity areas surrounding the bulk tumor mass. The mechanisms of this increased fluid attraction and the cellular composition of the microenvironment are only partially understood. In this study, we focus on imaging perifocal edema in orthotopically implanted gliomas in rodents and correlate perifocal edema with immunohistochemical markers. We identified that areas of perifocal edema not only include the tumor invasion zone, but also are associated with increased glial fibrillary acidic protein (GFAP) and aquaporin-4 expression surrounding the bulk tumor mass. Moreover, a high number of activated microglial cells expressing CD11b and macrophage migration inhibitory factor (MIF) accumulate at the tumor border. Thus, the area of perifocal edema is mainly dominated by reactive changes of vital brain tissue. These data corroborate that perifocal edema identified in T2-weighted MR scans are characterized with alterations in glial cell distribution and marker expression forming an inflammatory tumor microenvironment. (Cancer Sci 2009; 100: 1856-1862).