Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus
Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus
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DOI：
10.1016/j.pan.2019.07.002
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发表时间：
2019-07-01
期刊：
影响因子：
3.6
通讯作者：
Koike, Kazuhiko
中科院分区：
文献类型：
--
作者：
Mizuno, Suguru;Isayama, Hiroyuki;Koike, Kazuhiko
目的：使用血浆游离氨基酸计算的多变量指数（PFAA指数）被报告为胰腺癌（PaC）的诊断生物标志物。虽然糖尿病（DM）有望成为PaC的早期诊断指标，但在DM患者中识别高危个体是必要的。我们评估了诊断率的PFAA指数PaC在DM患者。方法：我们比较了个人和那些没有DM的PFAA指数之间的诊断率。前瞻性招募病例和对照组，对照组以1：1的比例与年龄，性别和DM状态相匹配。结果：共有180例病例对照对被纳入分析。DM患病率为53.3%。PFAA指数的敏感性为66.7%，糖尿病和56.0%，在那些没有糖尿病（P 0.14），和特异性为92.7%，在对照组中，糖尿病和94.0%，在那些没有糖尿病（P=0.95）。结论：这个匹配的病例对照研究显示了一个相当的诊断率的PFAA指数的个人与糖尿病和那些PaC。PFAA指数可用作选定DM患者进一步诊断成像的生物标志物。(C)2019年[AP和EPC。Elsevier B.V.出版，保留所有权利。
Objectives: A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM.Methods: We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status.Results: A total of 180 case-control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P=0.95).Conclusions: This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM. (C) 2019 [AP and EPC. Published by Elsevier B.V. All rights reserved.