Human pre-implantation embryo development
Human pre-implantation embryo development
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DOI：
10.1242/dev.060426
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发表时间：
2012-03-01
期刊：
影响因子：
4.6
通讯作者：
Pera, Renee A. Reijo
中科院分区：
文献类型：
--
作者：
Niakan, Kathy K.;Han, Jinnuo;Pera, Renee A. Reijo
了解人类植入前发育对辅助生殖技术（ART）和基于人类胚胎干细胞（hESC）的治疗具有重要意义。由于资源有限，对人类发育早期阶段的细胞和分子机制知之甚少。尽管如此，非侵入性成像技术以及分子和基因组技术的最新进展有助于增加我们对人类发展这一迷人阶段的理解。在这里，我们总结了目前已知的人类植入前胚胎发育，并强调如何进一步研究人类植入前胚胎可用于改善ART和充分利用hESC的治疗目标的潜力。
Understanding human pre-implantation development has important implications for assisted reproductive technology (ART) and for human embryonic stem cell (hESC)-based therapies. Owing to limited resources, the cellular and molecular mechanisms governing this early stage of human development are poorly understood. Nonetheless, recent advances in non-invasive imaging techniques and molecular and genomic technologies have helped to increase our understanding of this fascinating stage of human development. Here, we summarize what is currently known about human pre-implantation embryo development and highlight how further studies of human pre-implantation embryos can be used to improve ART and to fully harness the potential of hESCs for therapeutic goals.