Change of urinary nitrogen excretion in response to low-protein diets in adults.
Change of urinary nitrogen excretion in response to low-protein diets in adults.
复制标题
成人低蛋白饮食引起的尿氮排泄变化。
DOI：
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发表时间：
1976
影响因子：
7.1
通讯作者：
N. Scrimshaw
中科院分区：
文献类型：
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作者：
W. Rand;V. Young;N. Scrimshaw
对年轻男性和老年女性的氮平衡研究数据进行了分析，以了解受试者从充足蛋白质饮食改为基本无蛋白质饮食后的尿氮排泄模式。单指数方程：y = P1e-p2t+P3，提供了数据的充分拟合，表明单池模型描述了这些饮食条件下尿氮排泄的适应性下降。估计参数的比较表明，年轻男性和老年女性的分数速率常数 P2 相同，但两组之间的其他系数有所不同，具体取决于它们是否以每天、每公斤体重、每单位肌酐排泄或每公斤体细胞质量表达。改变饮食和达到尿氮排泄新平衡之间的时间长度（ts，或稳定时间）定义为 ts = 1/p2 loge(p1/s)，其中 s 是拟合的标准误差。两组的平均稳定时间相同（4.5 天），95% 的受试者在 8 天内达到氮输出的新平衡。
Data from nitrogen balance studies in young men and elderly women were analyzed for the pattern of urinary nitrogen excretion after the subjects had changed from an adequate to an essentially protein-free diet. The single exponential equation: y = P1e-p2t+P3, provided an adequate fit of the data, suggesting that a single-pool model describes the adaptive decline in urinary nitrogen excretion under these dietary conditions. Comparisons of the estimated parameters showed that the fractional rate constant, P2, was the same for both the young men and elderly women, but that the other coefficients differed between the two groups depending upon whether they were expressed per day, per kg of body weight, per unit creatinine excreted, or per kg of body cell mass. The length of time between the change in diet and the attainment of a new equilibrium in urinary nitrogen excretion (ts, or time to stability) is defined as ts = 1/p2 loge(p1/s) where s is the standard error of the fit. The average time to stability was the same in both groups (4.5 days), and 95% of the subjects reached the new equilibrium in nitrogen output within 8 days.