EVIDENCE FOR BOTH HISTAMINE H1‐ AND H2‐RECEPTORS IN THE GASTRIC VASCULATURE OF THE CAT
EVIDENCE FOR BOTH HISTAMINE H1‐ AND H2‐RECEPTORS IN THE GASTRIC VASCULATURE OF THE CAT
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猫胃血管中存在组胺 H1 和 H2 受体的证据
DOI：
10.1111/j.1476-5381.1980.tb10878.x
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发表时间：
1980
影响因子：
7.3
通讯作者：
K. Shaw
中科院分区：
文献类型：
--
作者：
C. A. Harvey;D. Owen;K. Shaw
实验研究了猫胃血管对动脉内注射组胺的反应。在胃泵灌注恒定流速的实验中，动脉内快速注射组胺可引起剂量依赖性血管舒张。组胺的剂量反应曲线被新皮拉米右移，再被新皮拉米加西咪替丁右移。单独使用西咪替丁不会改变组胺剂量-反应曲线。组胺和组胺拮抗剂之间的相互作用与在其他血管床中观察到的相互作用非常相似。用电磁流量探头测量，动脉内输注组胺也引起血管舒张，胃血流量增加。在每次输注期间，甲皮拉米减少了血流量的立即增加，尽管输注后期的反应没有改变。西咪替丁对即时反应没有影响，但降低了对组胺的持续反应。需要用甲皮拉米和西咪替丁治疗以消除组胺反应。注射2 -（2 -氨基乙基）吡啶和地马匹利也能增加胃血流量。这些结果表明H1‐和H2‐受体都参与组胺诱导的胃血管扩张。组胺和血管组胺受体之间的相互作用似乎有一个时间基础；H1受体反应先于H2受体反应。
1 Experiments have been done to study the gastric vascular response to histamine given intra‐arterially in the cat. 2 In experiments utilising pump perfusion of the stomach at constant flow rates, rapid intra‐arterial injections of histamine elicited dose‐dependent vasodilatation. The dose‐response curve to histamine was displaced to the right by mepyramine and further to the right by mepyramine plus cimetidine. Cimetidine alone did not displace the histamine dose‐response curve. This interaction between histamine and histamine antagonists is very similar to the interaction observed in other vascular beds. 3 Intra‐arterial infusions of histamine also caused vasodilatation with increased gastric blood flow, measured with an electromagnetic flow probe. Mepyramine reduced the immediate increase in blood flow during each infusion, although responses in the later stages of the infusions were unaltered. Cimetidine had no effect on the immediate response but reduced sustained responses to histamine. Treatment with mepyramine and cimetidine was required to abolish histamine responses. 4 Infusions of 2‐(2‐aminoethyl) pyridine and dimaprit also increased gastric blood flow. 5 These results indicate the involvement of both H1‐ and H2‐receptors in histamine‐induced gastric vasodilatation. There appears to be a time‐base in the interaction between histamine and vascular histamine receptors; H1‐receptor responses preceding H2‐receptor responses.