Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania
Usefulness of Highly Active Antiretroviral Therapy on Health-Related Quality of Life of Adult Recipients in Tanzania
复制标题
DOI：
10.1089/apc.2008.0278
复制
发表时间：
2009-07-01
影响因子：
4.9
通讯作者：
Yamamoto, Taro
中科院分区：
文献类型：
--
作者：
Magafu, Mgaywa G. M. D.;Moji, Kazuhiko;Yamamoto, Taro
这项研究评估了18岁或18岁以上的高效抗逆转录病毒疗法(HAART)接受者的健康相关生活质量(HRQOL)及其相关因素，这是在坦桑尼亚卡盖拉开始HAART治疗2年后进行的。2007年5月，采用36项简表健康调查(SF-36)，对329名接受HAART的患者进行了访谈。增加了关于社会人口学特征、慢性病(除艾滋病毒/艾滋病外)、HAART副作用和抗逆转录病毒药物依从性的问题。治疗数据，第一次和最新的可用的CD4计数从患者的记录中检索。样本的性别和年龄调整后的平均量表分数与20世纪90年代末坦桑尼亚普通人群的平均分数进行了t检验。Logistic回归分析性别、年龄、文化程度、经济收入、慢性病、CD4计数、HAART副作用、抗逆转录病毒药物依从性等因素对受者躯体功能和心理健康量表评分的影响。除一般健康认知(p=0.191)和心理健康(p=0.161)外，接受高强度抗逆转录病毒治疗的受试者的平均量表得分普遍低于一般人群。患有慢性病的HAART受试者在精神健康方面的得分更有可能低于一般人群的平均得分(p=0.007)。虽然慢性疾病共病对那些CD4计数增加的人的身体功能的影响是负面的(优势比[OR]=13.6，95%可信区间[CI]=3.7，49.9)，但对那些没有这种增加的人没有影响。应优先控制受者慢性病，提高受者的HRQOL。
This study assessed health-related quality of life (HRQOL) of highly active antiretroviral therapy (HAART) recipients aged 18 or older and associated factors, 2 years after HAART administration had started in Kagera, Tanzania. Using the 36-Item Short Form Health Survey (SF-36), 329 HAART recipients were interviewed in May 2007. Questions on sociodemographic characteristics, chronic diseases (besides HIV/AIDS), HAART side effects and adherence to antiretroviral drugs were added. Treatment data, the first and latest available CD4 counts were retrieved from patients' records. Gender and age-adjusted mean scale scores of the sample were compared to those of the general Tanzanian population of the late 1990s using t test. Logistic regression was used to explore the effect of sex, age, education level, income, chronic diseases, CD4 count, HAART side effects and adherence to antiretroviral drugs on recipients' physical functioning and mental health scale scores. The mean scale scores of HAART recipients were generally lower than those of the general population except for general health perceptions (p = 0.191) and mental health (p = 0.161). HAART recipients with chronic disease comorbidity were more likely to score below the general population's mean score for mental health (p = 0.007). While the effect of chronic disease comorbidity on physical functioning among those who recorded a CD4 count increase was negative (odds ratio [OR] = 13.6, 95% confidence interval [CI] = 3.7, 49.9), there was no effect on those who did not have such an increase. The control of chronic diseases among recipients should be given priority to improve their HRQOL.