Serotonergic basis of antipsychotic drug effects in schizophrenia
Serotonergic basis of antipsychotic drug effects in schizophrenia
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DOI：
10.1016/s0006-3223(98)00187-5
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发表时间：
1998-12-01
影响因子：
10.6
通讯作者：
Kraus, JE
中科院分区：
文献类型：
--
作者：
Lieberman, JA;Mailman, RB;Kraus, JE
最近的注意力集中在血清素（5-HT）在精神分裂症病理生理学中的参与及其在介导抗精神病药物作用中的作用。新的重点有两个原因：所谓的“非典型”抗精神病药物的巨大成功（其共同特征是它们对特定的5-HT受体亚型具有高亲和力）；并阐明了一个复杂的 5-HT 受体家族，其功能和药理学才刚刚开始被了解。本文将回顾有关 5-HT 在介导抗精神病药物作用中的作用的证据。将回顾多巴胺和 5-HT 系统的相互作用，并在此背景下评估非典型抗精神病药物的作用机制。将讨论血清素对神经发育的影响，以及血清素与致幻剂的拟精神病和致精神病特性的关系。这些事实将放在精神分裂症血清素能功能变化的背景下。 (C) 1998 年生物精神病学协会。
Recent attention has been focused on the involvement of serotonin (5-HT) in the pathophysiology of schizophrenia and its role in mediating antipsychotic drug effects. There are two reasons for the new emphasis: the tremendous success of the so-called "atypical" antipsychotic drugs (a common feature of which is their high affinity for specific: 5-HT receptor subtypes); and the elucidation of a complex family of 5-HT receptors whose function and pharmacology is only beginning to be understood. This paper will review the evidence that pertains to the role of 5-HT in mediating antipsychotic drug effects. The interaction of dopamine and 5-HT systems will be reviewed, and the mechanisms of action of atypical antipsychotic drugs will be evaluated in this context. The impact of serotonin on neurodevelopment, and the involvement of serotonin in the psychotomimetic and psychotogenic properties of hallucinogens, will be discussed Together, these facts will be placed into the context of changes in serotonergic function in schizophrenia. (C) 1998 Society of Biological Psychiatry.