Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions.
Rational design of hyperpolarized xenon NMR molecular sensor for the selective and sensitive determination of zinc ions.
复制标题
合理设计超极化氙核磁共振分子传感器，用于选择性、灵敏测定锌离子。
DOI：
10.1016/j.talanta.2014.01.023
复制
发表时间：
2014
期刊：
影响因子：
6.1
通讯作者：
Xin Zhou
中科院分区：
文献类型：
--
作者：
Ji Zhang;Weiping Jiang;Qing Luo;Xiaoxiao Zhang;Qianni Guo;Maili Liu;Xin Zhou
虽然Zn2+离子参与了大量的生理病理过程，但不透明生物样品中Zn2+离子的非侵入性检测仍然是一个巨大的挑战。在这里，我们开发了一种新的锌响应超极化（HP）129Xe为基础的NMR分子传感器。以2-（二苯基膦基）苯胺为锌离子的配体，将其连接到具有氙键合的超分子笼-隐闪石（cryptophane）上，合成了HP129Xe核磁共振分子传感器。该分子传感器在Zn~（2+）存在下的~（129）H NMR谱线位移高达6.4ppm，比已报道的同类传感器的位移大近4倍。该传感器的应用将有利于利用间接NMR/MRI方法进行低浓度检测。与其他6种金属离子相比，该方法具有较高的灵敏度和选择性.并对该传感器在大鼠血清样品中锌离子分析中的应用进行了评价。该策略可用于开发灵敏度高、选择性好的锌离子定量传感器。
Although Zn2+ions are involved in large numbers of physiopathological processes, non-invasive detection of Zn2+ions in opaque biological samples remains a huge challenge. Here, we developed a novel zinc-responsive hyperpolarized (HP)129Xe-based NMR molecular sensor. This HP129Xe-based NMR molecular sensor was synthesized by attaching 2-(diphenylphosphino) benzenamine as ligand for zinc ions to the xenon-binding supramolecular cage, cryptophane. The129Xe NMR spectroscopy of such molecular sensor was shifted up to 6.4 ppm in the presence of Zn2+ions, which was nearly four times larger than that of the reported similar sensor. The application of the sensor would benefit low concentration detection by using indirect NMR/MRI method. The response exhibited high sensitivity and selectivity as discriminated from other six potentially competing metal ions. The application of this sensor in the analysis of zinc ions in the rat serum samples was also evaluated. The strategy is generally applicable in developing sensitive and selective sensors for quantitative determination of zinc ions.
影响因子：
15
作者：
Wei, Qian;Seward, Garry K.;Dmochowski, Ivan J.
通讯作者：
Dmochowski, Ivan J.