Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling
Cortical spreading depression produces long-term disruption of activity-related changes in cerebral blood volume and neurovascular coupling
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DOI：
10.1117/1.1852556
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Toga, AW
中科院分区：
文献类型：
--
作者：
Guiou, M;Sheth, S;Toga, AW
皮质扩散抑制 (CSD) 是神经元和神经胶质细胞的明显去极化，在整个皮质中缓慢扩散，随后会出现一段时间的电生理活动抑制。与CSD相关的血管变化是血流量的短暂大幅增加，随后是持续超过1小时的长时间减少。目前，该低血容量期间功能性血管活动的概况尚未得到很好的表征。基于灌注的成像技术，例如功能磁共振成像（fMRI），假设神经元和血管活动的变化之间存在紧密耦合。在正常情况下，这些变量具有良好的相关性。表征 CSD 对这种关系的影响是了解急性病理生理事件可能对神经血管耦合影响的重要一步。我们研究了 CSD 对 CSD 诱导后 1 小时内皮质电生理活动引起的脑血容量 (CBV) 功能变化的影响。 CBV 信号幅度、持续时间和达到峰值的时间在诱导后 60 分钟几乎没有恢复。自发血管舒缩活动的分析表明，血管反应性的降低可能在正常功能性 CBV 反应的破坏中发挥重要作用。电生理活动也减弱，但程度较小。 CSD 后 CBV 和诱发电位没有很好的相关性，表明神经血管耦合关系破裂。 (c) 2005 年光电仪器工程师协会。
Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads slowly across the cortex followed by a period of depressed electrophysiological activity. The vascular changes associated with CSD are a large transient increase in blood flow followed by a prolonged decrease lasting greater than I h. Currently, the profile of functional vascular activity during this hypovolemic period has not been well characterized. Perfusion-based imaging techniques such as functional magnetic resonance imaging (fMRI) assume a tight coupling between changes in neuronal and vascular activity. Under normal conditions, these variables are well correlated. Characterizing the effect of CSD on this relationship is an important step to understand the impact acute pathophysiological events may have on neurovascular coupling. We examine the effect of CSD on functional changes in cerebral blood volume (CBV) evoked by cortical electrophysiological activity for I h following CSD induction. CBV signal amplitude, duration, and time to peak show little recovery at 60 min post-induction. Analysis of spontaneous vasomotor activity suggests a decrease in vascular reactivity may play a significant role in the disruption of normal functional CBV responses. Electrophysiological activity is also attenuated but to a lesser degree. CBV and evoked potentials are not well correlated following CSD, suggesting a breakdown of the neurovascular coupling relationship. (c) 2005 Society of Photo-Optical Instrumentation Engineers.