Control strategies of 3-cell Central Pattern Generator via global stimuli.
Control strategies of 3-cell Central Pattern Generator via global stimuli.
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DOI：
10.1038/srep23622
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发表时间：
2016-03-29
影响因子：
4.6
通讯作者：
Barrio R
中科院分区：
文献类型：
--
作者：
Lozano Á;Rodríguez M;Barrio R
控制多种生物过程的小神经元网络的同步模式的研究已经成为一个有趣的成长学科。个别神经元的这些同步模式中的一些与一些不良的神经系统疾病有关，并且它们被认为在不同疾病（如帕金森病）中病理性节律性大脑活动的出现中起着至关重要的作用。我们展示了如何在整个网络中适当组合短而弱的全局抑制性和兴奋性刺激，我们可以在小神经元网络（在我们的情况下是3-神经元网络）中的不同稳定突发模式之间切换。我们开发了一个系统的研究，显示和解释在不同时刻应用脉冲的效果。此外，我们比较了一个完全对称的网络上的技术和一个稍微扰动的（一个更现实的情况）。使用全局刺激的本方法可以允许避免与非攻击性刺激的不期望的同步模式。
The study of the synchronization patterns of small neuron networks that control several biological processes has become an interesting growing discipline. Some of these synchronization patterns of individual neurons are related to some undesirable neurological diseases, and they are believed to play a crucial role in the emergence of pathological rhythmic brain activity in different diseases, like Parkinson’s disease. We show how, with a suitable combination of short and weak global inhibitory and excitatory stimuli over the whole network, we can switch between different stable bursting patterns in small neuron networks (in our case a 3-neuron network). We develop a systematic study showing and explaining the effects of applying the pulses at different moments. Moreover, we compare the technique on a completely symmetric network and on a slightly perturbed one (a much more realistic situation). The present approach of using global stimuli may allow to avoid undesirable synchronization patterns with nonaggressive stimuli.