Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis.
Ethical Aspects of Brain Organoid Research in News Reports: An Exploratory Descriptive Analysis.
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DOI：
10.3390/medicina57060532
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发表时间：
2021-05-27
期刊：
影响因子：
--
通讯作者：
Fujita M
中科院分区：
文献类型：
--
作者：
Ide K;Matsuoka N;Fujita M
背景和目的：脑类器官是由多能干细胞产生的自组装的三维聚集体。这些模型对人类大脑发育和功能的实验研究很有用，因此越来越多地用于世界各地的研究。由于脑类器官的使用越来越多，引发了一些伦理问题，我们的目的是利用一个横断面数据库来评估媒体对脑类器官研究的现状，以了解公众对这一主题的讨论程度。材料和方法：我们对从Nexis Uni数据库获得的新闻报道进行了描述性分析，该数据库于2020年4月检索。在提取新闻报道后，对每年的报道数量和纳入的术语进行分析。结果：截至2020年4月，共发表新闻报道332篇，其中一半以上发表在美国和英国，且每年都在逐渐增加。共有113篇（34.0%）新闻报道包含伦理学相关关键词，研究周期中点前后的研究比例显著增加（2013-2016年21.0% vs 2017-2020年38.2%）；p = 0.0066，经Yates连续性校正的卡方检验)。结论：虽然关于类脑器官研究伦理方面的新闻报道逐渐增多，但在发表区域存在偏倚。关注类脑器官研究的伦理方面的其他研究应努力评估世界不同地区公众对这一主题的看法。
Background and Objectives: Brain organoids are self-assembled, three-dimensional (3D) aggregates generated from pluripotent stem cells. These models are useful for experimental studies on human brain development and function and are therefore increasingly used for research worldwide. As their increasing use raises several ethical questions, we aimed to assess the current state of the press on brain organoid research using a cross-sectional database to understand the extent of discussion of this subject in the public. Materials and Methods: We conducted a descriptive analysis of news reports obtained from the Nexis Uni database, searched in April 2020. After extracting the news reports, the number of published reports in each year and the included terms were analyzed. Results: Up to April 2020, 332 news reports had been published, with over half of them published in the United States and the United Kingdom, with the numbers gradually increasing every year. In total, 113 (34.0%) news reports included ethics-related keywords, and the ratio of studies before and after the study-period midpoint was significantly increased (21.0% (2013–2016) vs. 38.2% (2017–2020); p = 0.0066, Chi-square test with Yates’ continuity correction). Conclusions: Although news reports on the ethical aspects of brain organoid research have been increasing gradually, there was a bias in the region of publication. Additional studies focusing on the ethical aspects of brain organoid research should strive to assess the public perception on the subject in different parts of the world.
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影响因子：
64.5
作者：
Mariani J;Coppola G;Zhang P;Abyzov A;Provini L;Tomasini L;Amenduni M;Szekely A;Palejev D;Wilson M;Gerstein M;Grigorenko EL;Chawarska K;Pelphrey KA;Howe JR;Vaccarino FM
通讯作者：
Vaccarino FM
影响因子：
23.9
作者：
Bershteyn M;Nowakowski TJ;Pollen AA;Di Lullo E;Nene A;Wynshaw-Boris A;Kriegstein AR
通讯作者：
Kriegstein AR
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
64.8
作者：
Farahany NA;Greely HT;Hyman S;Koch C;Grady C;Pașca SP;Sestan N;Arlotta P;Bernat JL;Ting J;Lunshof JE;Iyer EPR;Hyun I;Capestany BH;Church GM;Huang H;Song H
通讯作者：
Song H
影响因子：
8.8
作者：
Iefremova, Vira;Manikakis, George;Ladewig, Julia
通讯作者：
Ladewig, Julia