Journal of Oral Biology and Craniofacial Research 3D bioprinting and craniofacial regeneration
Journal of Oral Biology and Craniofacial Research 3D bioprinting and craniofacial regeneration
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口腔生物学和颅面研究杂志 3D 生物打印和颅面再生
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通讯作者：
M. Sakon
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作者：
Daisaku Yamada;Hidenori Takahashi;K. Asukai;Shinichiro Hasegawa;H. Wada;C. Matsuda;M. Yasui;T. Omori;H. Miyata;M. Sakon
A B S T A背景：考虑到颅面组织的结构和功能的复杂性，3D生物打印可以是一种有价值的工具，用于设计和创建用于体内应用的功能性3D组织或器官。本文旨在探讨这种新兴的3D生物打印技术的各个方面及其在颅面骨或软骨再生中的应用。方法：在pubmed、google scholar、medline、embase和sci- ence direct上进行了电子数据库检索，以获得针对颅面再生的3D生物打印发表的英文文献。使用的搜索项是“颅面再生”或“颌骨再生”或“颌面再生”和“3D生物打印”或“三维生物打印”或“增材制造”或“快速原型”或“患者特异性生物打印”。排除了评论和重复。结果：按上述检索标准共检索到476篇文献，排除综述后减少到108篇。进一步筛选单个文章，得到77篇文章，其中9篇额外文章从参考文献中纳入，18篇重复文章被排除。最后，我们留下了68篇文章纳入审查。结论：据报道，使用具有不同生物材料的生物墨水并在3D生物打印机中掺入干细胞，颅面组织和器官再生取得了成功。尽管已经进行了几次尝试来制造颅面骨和软骨，但仍在继续努力实现期望的结果。
A B S T A Background: Considering the structural and functional complexity of the craniofacial tissues, 3D bioprinting can be a valuable tool to design and create functional 3D tissues or organs in situ for in vivo applications. This review aims to explore the various aspects of this emerging 3D bioprinting technology and its application in the cra- niofacial bone or cartilage regeneration. Method: Electronic database searches were undertaken on pubmed, google scholar, medline, embase, and sci- ence direct for english language literature, published for 3D bioprinting in craniofacial regeneration. The search items used were ‘craniofacial regeneration’ OR 'jaw regeneration' OR 'maxillofacial regeneration' AND ‘3D bioprinting’ OR 'three dimensional bioprinting' OR 'Additive manufacturing' OR 'rapid prototyping' OR 'patient specific bioprinting'. Reviews and duplicates were excluded. Results: Search with above described criteria yielded 476 articles, which reduced to 108 after excluding reviews. Further screening of individual articles led to 77 articles to which 9 additional articles were included from references, and 18 duplicate articles were excluded. Finally we were left with 68 articles to be included in the review. Conclusion: Craniofacial tissue and organ regeneration has been reported a success using bioink with different biomaterial and incorporated stem cells in 3D bioprinters. Though several attempts have been made to fabricate craniofacial bone and cartilage, the strive to achieve desired outcome still continues.