Progressive entorhinal cortex lesions accelerate hippocampal sprouting and spare spatial memory in rats.
Progressive entorhinal cortex lesions accelerate hippocampal sprouting and spare spatial memory in rats.
复制标题
进行性内嗅皮层损伤加速大鼠海马萌芽并保留空间记忆。
DOI：
10.1073/pnas.93.26.15512
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发表时间：
1996
影响因子：
11.1
通讯作者：
Kelley,MS
中科院分区：
文献类型：
--
作者：
Ramirez,JJ;McQuilkin,M;Carrigan,T;MacDonald,K;Kelley,MS
通过对内嗅皮层进行单侧渐进性损伤来加速海马发芽，从而使大鼠的空间记忆免于保留学习交替任务。随后横切发芽交叉颞齿通路（CTD），以及同时CTD横切和进行性内嗅病变，产生了持久的赤字的记忆任务。这些结果表明，CTD发芽，这是同源的原始穿孔路径输入到海马齿状回，是行为上显着的，可以改善至少一些与海马传入阻滞相关的记忆缺陷。
Accelerating hippocampal sprouting by making unilateral progressive lesions of the entorhinal cortex spared the spatial memory of rats tested for retention of a learned alternation task. Subsequent transection of the sprouted crossed temporodentate pathway (CTD), as well as a simultaneous CTD transection and progressive entorhinal lesion, produced a persistent deficit on the memory task. These results suggest that CTD sprouting, which is homologous to the original perforant path input to the dentate gyrus of the hippocampus, is behaviorally significant and can ameliorate at least some of the memory deficits associated with hippocampal deafferentation.