A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T
A large volume double channel 1H-X RF probe for hyperpolarized magnetic resonance at 0.0475 T
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DOI：
10.1016/j.jmr.2012.04.012
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发表时间：
2012-07-01
影响因子：
2.2
通讯作者：
Chekmenev, Eduard Y.
中科院分区：
文献类型：
--
作者：
Coffey, Aaron M.;Shchepin, Roman V.;Chekmenev, Eduard Y.
在这项工作中，我们描述了一种大体积 340 mL H-1-X 磁共振 (MR) 探针，用于研究 0.0475 T 的超极化化合物。H-1/C-13 和 H-1/N-15 探针配置被证明具有扩展到 H-1/Xe-129 的潜力。该探针的主要应用是使用 PASADENA（仲氢和合成可显着增强核排列）和其他基于仲氢的超极化方法制备 C-13 和 N-15 超极化造影剂并保证质量。该探头高效，可在 5.3 W 下发出 62 μs C-13 激励脉冲，适合便携式操作。该探头调谐至 C-13 的灵敏度和检测限与在 4.7 T 下工作的商用射频 (RF) 线圈进行了比较。我们证明超极化造影剂的低场 MR 可以与传统的高场检测一样灵敏，并概述了临床前体内 MRI 探头设计的潜在改进和优化。 PASADENA 应用这种低功率探针的例子是 C-13 超极化丙酸 2-羟乙酯-1-C-13,2,3,3-d(3)。 (C) 2012 Elsevier Inc. 保留所有权利。
In this work we describe a large volume 340 mL H-1-X magnetic resonance (MR) probe for studies of hyperpolarized compounds at 0.0475 T. H-1/C-13 and H-1/N-15 probe configurations are demonstrated with the potential for extension to H-1/Xe-129. The primary applications of this probe are preparation and quality assurance of C-13 and N-15 hyperpolarized contrast agents using PASADENA (parahydrogen and synthesis allow dramatically enhanced nuclear alignment) and other parahydrogen-based methods of hyperpolarization. The probe is efficient and permits 62 mu s C-13 excitation pulses at 5.3 W. making it suitable for portable operation. The sensitivity and detection limits of this probe, tuned to C-13, are compared with a commercial radio frequency (RF) coil operating at 4.7 T. We demonstrate that low field MR of hyperpolarized contrast agents could be as sensitive as conventional high field detection and outline potential improvements and optimization of the probe design for preclinical in vivo MRI. PASADENA application of this low-power probe is exemplified with C-13 hyperpolarized 2-hydroxyethyl propionate-1-C-13,2,3,3-d(3). (C) 2012 Elsevier Inc. All rights reserved.